Publications by authors named "R Zengin"
Data in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions. Our study aimed to evaluate the effect of CAZ-AVI use on outcomes in CRKP-BSIs in Turkey, where OXA-48 is endemic. A multicenter retrospective observational study was conducted between January 2017 and September 2021.
View Article and Find Full Text PDF: Ceftazidime-avibactam (CAZ-AVI) is recommended as first-line treatment for Oxacillinase-48 (OXA-48) β-Lactamase-producing carbapenem-resistant Enterobacterales (CRE) infections, while polymyxin-based combination therapies (PBCTs) are used as a last resort when CAZ-AVI is unavailable. Research comparing the effectiveness of CAZ-AVI and PBCT in CRE blood stream infections (CRE-BSIs) is limited, mostly focusing on carbapenemase (KPC)-producing isolates. In Turkey, OXA-48 is endemic and OXA-48-Like is common.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the effects of immunosuppressant medications like methylprednisolone, dexamethasone, and tocilizumab on secondary infections in COVID-19 patients in ICUs from March 2020 to October 2021.
- It involved 412 patients divided into three groups based on their treatment: no immunosuppressants, some immunosuppressants, and all three studied agents, with findings showing higher rates of secondary infections and longer ICU stays in those receiving more extensive treatment.
- Ultimately, while mortality rates were similar between the no and some treatment groups, those receiving all three agents had significantly higher mortality rates, indicating potential risks of immunosuppressant use in
Introduction: We compared the diagnostic values of individual and composite biomarkers used in the prediction of bacteremia in adult emergency department patients.
Methodology: First-hour blood levels of C- reactive protein, procalcitonin, interleukin-6, lactate, lipopolysaccharide-binding protein and white blood cell count were collected from a 30-person control group and 47 adult patients. Patients included in this study were admitted to the emergency department on suspicion of sepsis.
Objective: Viral load varies during infection and is higher during the initial stages of disease. Given the importance of the intensive care unit (ICU) in the late stages of COVID-19 infection, analyzing cycle threshold values to detect viral load upon ICU admission can be a clinically valuable tool for identifying patients with the highest mortality risk.
Methods: This was a retrospectively designed study.