Publications by authors named "R Zalubovskis"
Surface modification is essential in microfluidic applications due to the inherent hydrophobicity of polymers, which can lead to biofouling and reagent denaturation. Despite the development, challenges such as hydrophobic molecule absorption and limitations in scaling are still present. Off-stoichiometry thiol-ene (OSTE) materials have emerged as a promising alternative, offering advantages like rapid prototyping, minimal hydrophobic absorption, and customizable surface chemistries.
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- A series of thirteen cyclic sulfonyl guanidines were developed and tested for their effectiveness against tumor-associated hCA IX and hCA XII isoforms, with minimal activity against off-target isoforms hCA I and hCA II.
- All tested compounds showed moderate inhibition of the target isoforms, with K values ranging from 0.57 to 8.4 µM for hCA IX and 0.34 to 9.7 µM for hCA XII.
- Due to their selectivity towards the target isoforms, these compounds hold potential as starting points for creating more effective antitumor treatments.
A novel series of hydantoins incorporating phthalimides has been synthesised by condensation of activated phthalimides with 1-aminohydantoin and investigated for their inhibitory activity against a panel of human (h) carbonic anhydrase (CA, EC 4.2.1.
View Article and Find Full Text PDFA novel series of sulfonamide-incorporated bis(α-aminophosphonates) acting as effective carbonic anhydrase (CA, EC 4.2.1.
View Article and Find Full Text PDFWe aimed to design and synthesize 3-methylenechroman-2-one derivatives and test their potency as TrxR1 inhibitors. A convenient and easy-to-handle synthetic approach to 3-methylenechroman-2-ones was developed. The in vitro inhibitory activity towards recombinant TrxR1 was determined for the obtained compounds.
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