Publications by authors named "R Z Shaikhutdinova"
Goal: Presentation of the first Russian computer program (www.carotidscore.ru) for risk stratification of postoperative complications of carotid endarterectomy (CEE).
View Article and Find Full Text PDFTo develop a modern plague vaccine, we used hypo-endotoxic bacterial ghosts (BGs) with combinations of genes encoding the bacteriophage ɸX174 lysis-mediating protein E and/or holin-endolysin systems from λ or L-413C phages. Expression of the protein E gene resulted in the BGs that retained the shape of the original bacterium. Co-expression of this gene with genes coding for holin-endolysin system of the phage L-413C caused formation of structures resembling collapsed sacs.
View Article and Find Full Text PDFArticle Synopsis
- The outer membrane of gram-negative bacteria, particularly in Yersinia pestis (the plague-causing bacterium), plays a crucial role in its ability to survive and thrive in hosts by resisting immune responses and antibiotics.
- The proteins Ail and lipopolysaccharide (LPS) work together to enhance bacterial virulence by modifying the membrane structure and thickness, which helps the bacteria avoid detection and destruction by the human immune system.
- The study emphasizes the significance of the combined action of Ail and LPS, suggesting that targeting this interaction could offer new strategies for combating Y. pestis infections.
To identify Yersinia pestis genes involved in the microbe's resistance to cationic antimicrobial peptides, the strategy of random transposon mutagenesis with a Tn5 minitransposon was used, and the library was screened for detecting polymyxin B (PMB) susceptible mutants. The mutation responsible for PMB-sensitive phenotype and the lipopolysaccharide (LPS) structure were characterized for the Y. pestis strain KM218-A3.
View Article and Find Full Text PDFMild acid degradation of the lipopolysaccharide of Yersinia kristensenii C-134 afforded a glycerol teichoic acid-like O-polysaccharide, which was studied by sugar analysis, O-deacetylation and dephosphorylation along with 1D and 2D NMR spectroscopy. The following structure of the O-polysaccharide was established: This structure is related to those of other Y. kristensenii O-polysaccharides studied earlier.
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