The S-Phase Arrest of Host Cells Caused by an Alpha-Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes.

Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while certain herpesviruses can enhance viral gene transcription by altering the RNA Pol II location, modulating its phosphorylation, or directly interacting with RNA Pol II. However, the influence of herpesviruses on RNA Pol II transcription extends beyond these direct effects. Here, we present a novel mechanism by which the host cell cycle regulates viral gene transcription via RNA Pol II during infection by Anatid Herpesvirus 1 (AnHV-1), an avian alpha-herpesvirus.

Mechanism of microscopic behind the influence of stress loading on gas adsorption by coal.

This study aims to explore the mechanism behind the influence of stress on gas adsorption by coal during deep mining and improve the accuracy of gas disaster prevention and control. To achieve this aim, thermodynamic analysis was conducted on the process of gas adsorption by loaded coal, and modified thermodynamic model proposed by previous scholars. It is found that stress plays an important role in gas adsorption by coal.

Co-Optimization Operation of Distribution Network-Containing Shared Energy Storage Multi-Microgrids Based on Multi-Body Game.

Under the carbon peaking and carbon neutrality target background, efficient collaborative scheduling between distribution networks and multi-microgrids is of great significance for enhancing renewable energy accommodation and ensuring stable system operation. Therefore, this paper proposes a collaborative optimization method for the operation of distribution networks and multi-microgrids with shared energy storage based on a multi-body game. The method is modeled and solved in two stages.

Alternative Splicing: Emerging Roles in Anti-Aging Strategies.

Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence. Significant changes to alternative splicing, including dysregulated splicing events and the abnormal expression of splicing factors, have been detected during the aging process or in age-related disorders.

Effects of Different River Crab Polyculture Practices on Bacterial, Fungal and Protist Communities in Pond Water.

Microorganisms, including bacteria, fungi, and protists, are key drivers in aquatic ecosystems, maintaining ecological balance and normal material circulation, playing vital roles in ecosystem functions and biogeochemical processes. To evaluate the environmental impact of different river crab polyculture practices, we set up two different river crab () polyculture practices: one where river crabs were cultured with mandarin fish (), silver carp (), and freshwater fish stone moroko (), and another where river crabs were cultured just with mandarin fish and silver carp. These two polyculture practices were referred to as PC and MC, respectively.