Prevalence of components of the metabolic syndrome according to birthweight among overweight and obese children and adolescents.

Background/objectives: Extremes of birthweight (BW) have been associated with increased rates of metabolic risks. The objective was to study the prevalence of metabolic risks markers among obese and overweight (OW) subjects according to BW.

Subjects/methods: A cross-sectional study was performed in a cohort of 1002 patients (2-18 years, 40.

Ghrelin plasma levels in patients with idiopathic short stature.

Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short stature have been reported.

Aim: To study plasma ghrelin levels in prepubertal patients with idiopathic short stature (ISS).

[Precocious pubarche: experience in 173 cases ].

Background: Precocious pubarche (PP), defined as the development of sexual pubic hair before 8 years of age in females and before 9 years in males, is usually a benign condition but it can also be the first sign of an underlying disease.

Aim: To analyze the etiology and perform a short term follow up in a cohort of patients with PP.

Material And Methods: A group of 173 patients (158 females) consulted for PP with a mean age of 7.

[Effectiveness of Leuprolide acetate therapy every three months in central precocious puberty].

Background: Precocious puberty may reduce final adult height, and affected children may suffer social and emotional problems. The efficacy of treatment with a long acting agonist analogue of the gonadotropin releasing hormone (aLHRH) has been well demonstrated.

Aim: To evaluated the efficacy of a new formulation of aLHRH (leuprolide, Lupron) for the suppression of gonadotropin activation and clinical signs of puberty.

[Consensus on the diagnosis and treatment of central early puberty].

The beginning of puberty is marked by breast growth in girls and testicular enlargement in boys. These occur at the age of 10.5 +/- 2.