Publications by authors named "R Yoshikawa"
Strain-promoted azide-alkyne cycloaddition enhanced by secondary interactions.
Org Biomol Chem
January 2025
Azide-alkyne cycloaddition of cyclooct-2-yn-1-ol and 2-(azidophenyl)boronic acid proceeded rapidly at room temperature with complete regioselectivity to afford a triazole having a boronate ester group. The secondary interaction to form a boronate ion contributed to cycloaddition rate acceleration and the control of regioselectivity. The interaction to form an imine or hemiaminal was also evaluated.
View Article and Find Full Text PDFThe real-world treatment patterns at medical facilities and their physicians' specialties treating migraine have not been fully investigated in Japan. Therefore, a retrospective cohort study aimed to describe real-world clinical practice and treatment patterns in Japanese patients with migraine according to medical facilities and physicians' specialties. Anonymized claims data of patients with migraine was obtained from JMDC Inc (January 2018-June 2023).
View Article and Find Full Text PDFRecent advances in low-dimensional materials have enabled the synthesis of single-walled carbon nanotubes encapsulated in hexagonal boron nitride (BN) nanotubes (SWCNT@BNNT), creating one-dimensional van der Waals (vdW) heterostructures. However, controlling the quality and crystallinity of BNNT on the surface of SWCNTs using chemical vapor deposition (CVD) remains a challenge. To better understand the growth mechanism of the BNNT in SWCNT@BNNT, we conducted molecular dynamics (MD) simulations using empirical potentials.
View Article and Find Full Text PDFArticle Synopsis
- - Low-intensity pulsed ultrasound (LIPUS) and transcutaneous carbon monoxide (CO) therapy were tested in rats to determine if their combined use would enhance fracture healing more effectively than using either treatment alone.
- - The study created femoral shaft fractures in rats and divided them into four groups: combination (LIPUS + CO), LIPUS only, CO only, and a control group, treating them regularly for four weeks and assessing bone healing through various methods.
- - Results showed that the combination group had significantly better fracture healing scores, higher vascular density, and increased gene expression related to bone growth compared to the control and single therapy groups at multiple time points throughout the study.
Background: PCI for aorto-ostial CTO remains challenging. The techniques for guidewire in aorto-ostial CTO may differ from those used in non-aorto-ostial CTOs, influenced by clinical and angiographic characteristics.
Objectives: This study aimed to assess the technical aspects and outcomes of percutaneous coronary intervention (PCI) in patients with aorto-ostial chronic total occlusion (CTO).