Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms.

Zinc transporters (ZnTs) act as H/Zn antiporters, crucial for zinc homeostasis. Brain-specific ZnT3 expressed in synaptic vesicles transports Zn from the cytosol into vesicles and is essential for neurotransmission, with ZnT3 dysfunction associated with neurological disorders. Ubiquitously expressed ZnT4 localized to lysosomes facilitates the Zn efflux from the cytosol to lysosomes, mitigating the cell injury risk.

Potential Benefits of and Gel for Prevention of Radiation-Induced Dermatitis in Head and Neck Cancer Patients.

Background: The main therapy for head and neck cancer is radiation, and one of the toxic effects of radiation is radiation dermatitis. is a species of succulent plant of the genus , widely used in cosmetic and skin care products, as well as daikon (), which is high in antioxidants.

Objectives: The present study aims to evaluate the potential benefits of and daikon gel combination in head and neck cancer patients to prevent radiation-induced dermatitis.

The Effect of Varying Slice Thickness and Interslice Gap on T and T Measured with the Multidynamic Multiecho Sequence.

Purpose: The purpose of our study was to investigate the effect of different slice thicknesses and/or interslice gaps on longitudinal and transverse relaxation times (T and T) measured by a multi-dynamic, multi-echo (MDME) sequence.

Materials And Methods: This retrospective study included nine healthy subjects who underwent MDME sequence (at 3T) with four different combinations of slice thicknesses and/or interslice gaps: slice thickness of 4 mm and interslice gap of 0 mm (TH4/G0), TH4/G1, TH5/G0, and TH5/G1. T and T were measured in various brain regions by a qualified neuroradiologist with 8 years of clinical experience: the frontal white matter (WM), occipital WM, genu, splenium, frontal cortex, thalamus, putamen, caudate head, and cerebrospinal fluid (CSF).

Gold(I)-catalyzed synthesis of optically active 1,4-oxazepan-7-ones.

Optically active seven-membered lactones, dimethyleneoxazepanones, were readily prepared in good yields from chiral β-(N-propargylic)amino-α-methylene carboxylic acid tert-butyl esters in the presence of catalytic amounts of Ph3PAuCl and Cu(OTf)2. A smooth 7-exo-dig cyclization was observed.

Preparation of optically active bicyclodihydrosiloles by a radical cascade reaction.

Bicyclodihydrosiloles were readily prepared from optically active enyne compounds by a radical cascade reaction triggered by tris(trimethylsilyl)silane ((Me3Si)3SiH). The reaction was initiated by the addition of a silyl radical to an α,β-unsaturated ester, forming an α-carbonyl radical that underwent radical cyclization to a terminal alkyne unit. The resulting vinyl radical attacked the silicon atom in an SHi manner to give dihydrosilole.