The Winner and still champion: Nodule volume doubling times.

There have been enormous advances in the approach to assessing malignancy status of indeterminate pulmonary nodules including risk models, image based biomarkers and numerous types of biologic and molecular markers. All of these have the advantage of guiding further workup once the nodule is identified. The traditional method, especially for smaller nodules relies primarily on assessing whether a nodule changes in size over time and is a feature in virtually every management protocol for both screen detected as well as incidentally detected nodules.

Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis.

Hormone-receptor-positive (HR) luminal cells largely mediate the response to estrogen and progesterone during mammary gland morphogenesis. However, there remains a lack of consensus on the precise nature of the precursor cells that maintain this essential HR lineage. Here we refine the identification of HR progenitors and demonstrate their unique regenerative capacity compared to mature HR cells.

GI cancer mortality in participants in low dose CT screening for lung cancer with a focus on pancreatic cancer.

Lung cancer, the leading cause of cancer deaths globally, has better survival rates with early detection. Annual low-dose CT (LDCT) screenings are recommended for high-risk individuals due to age and smoking. These individuals are also at risk for other cancers.

Predicted Effect of Incidental Pulmonary Nodule Findings on NSCLC Mortality.

Introduction: Despite the reduction in mortality by low-dose computed tomography lung cancer screening, the uptake is still low. Patients undergo chest imaging for several other medical reasons, and this is a unique opportunity to detect lung nodules.

Methods: In a cohort of patients with NSCLC from the Surveillance, Epidemiology, and End Results-Medicare-linked data, tumor size at previous imaging was calculated as follows: volume doubling time = [(T-T)·ln2]/ln(V/V), solving for the diameter of V.

Injectable Salecan/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair.

Designing materials for wound dressings with superior therapeutic benefits, self-healing and injectable characteristics is important in clinical practice. Herein, a new self-healing injectable hydrogel was prepared via thermal treatment and dynamic Schiff base reaction by mixing oxidized hyaluronic acid (OHA) and hydrazided Salecan (Sal-ADH). The versatility of the wound dressing was confirmed by studying the inherent rheological properties, high swelling rate, sustained-release behavior of the drug, pH/hyaluronidase-dependent biodegradation, in vitro antimicrobial as well as in vivo wound healing performance.