Publications by authors named "R Yasumatsu"
Article Synopsis
- Phase III KEYNOTE-048 study compared the effectiveness of pembrolizumab, pembrolizumab-chemotherapy, and cetuximab-chemotherapy (EXTREME) in Japanese patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) over 5 years.
- Results showed that patients receiving pembrolizumab had significantly higher 5-year overall survival rates compared to those on EXTREME, indicating its potential as a better first-line treatment option.
- Pembrolizumab-chemotherapy also demonstrated durability, but its survival rates were less consistent compared to pembrolizumab alone in the same population.
Most elements of filamentous fungi seen in human tissue by pathologists are hyphae, and encountering other elements may interfere with diagnosis. Sporangia and chlamydospores are such elements that have been described in only a few case reports. We present an autopsy case with the extremely rare coexistence of Mucorales sporangia and chlamydospores in the lung.
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- This study examined factors that predict how well head and neck cancer patients respond to nivolumab, an anti-PD-1 treatment, focusing on clinical, microenvironmental, and genomic aspects.
- It analyzed 100 patients, revealing that responders typically had lower smoking and drinking habits, more immune-related side effects, and higher PD-L1 expression compared to non-responders.
- Additionally, factors like age, previous treatment with cetuximab, and specific gene mutations affected the response to treatment, highlighting the complexity of immune responses in cancer therapy.
[Diagnostic yield and utility of boring biopsy for subepithelial lesions of the stomach and esophagus].
Nihon Shokakibyo Gakkai Zasshi
August 2024
Article Synopsis
- The study assessed the effectiveness of boring biopsy in diagnosing subepithelial lesions (SEL) in the stomach and esophagus, involving 52 patients.
- The diagnostic yield was found to be 50% for gastric SELs and 80% for esophageal SELs, with higher success rates for smaller lesions (less than 10mm).
- Complications occurred in 10% of stomach biopsies, including two perforations and two cases of bleeding, while gastrointestinal stromal tumors were identified in 43% of gastric cases and all esophageal SELs were leiomyomas.
The impact of sarcopenia in the treatment for patients with head and neck cancer.
Auris Nasus Larynx
August 2024
Sarcopenia is a disease in which a decline in muscle mass with age is associated with a decline in physical performance. In the field of otorhinolaryngology, head and neck surgery, sarcopenia is gaining attention as a cause of swallowing disorders and as a problem in the treatment of head and neck cancer. Head and neck cancer occurs in anatomical sites related to swallowing, so patients with head and neck cancer are prone to swallowing disorders and "nutrition-related sarcopenia.
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