Publications by authors named "R Yamakawa"
CDK8 inhibitor KY-065 rescues skeletal abnormalities in achondroplasia model mice.
Biochim Biophys Acta Mol Basis Dis
December 2024
Article Synopsis
- CDK8 is essential for bone health, and its inhibitor KY-065 has shown potential in preventing postmenopausal osteoporosis in mice.
- KY-065 has also been found to improve bone growth and chondrogenesis in a mouse model of achondroplasia (the most common form of genetic dwarfism), by targeting the STAT1 signaling pathway without affecting MAPK activation.
- The results suggest that CDK8 in chondrocytes could be a new target for treatment, with KY-065 emerging as a promising drug for achondroplasia.
Hydrogel carrier with bubble vibration enhancer for ultrasound-triggered drug release.
Ultrason Sonochem
January 2025
Hydrogel-based drug carriers provide on-demand drug release via external stimuli. Ultrasound is a promising method because of the potential for remotely releasing the drug. However, intense ultrasound irradiation has been required in previous studies.
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- Kuruma shrimp (Penaeus japonicus) adjust their levels of alanine, a free amino acid, to maintain osmotic pressure in response to changes in environmental salinity.
- The study involved cloning the alanine aminotransferase (ALT) gene, crucial for alanine production, revealing it as a 3,301 bp sequence that encodes a protein of 514 amino acids with conserved activity-related residues.
- Expression analysis showed that ALT1 mRNA levels in the shrimp significantly increased at higher salinities, particularly at 40‰, indicating its role in boosting alanine concentration in order to manage osmotic balance.