A MACPF Protein OsCAD1 Balances Plant Growth and Immunity Through Regulating Salicylic Acid Homeostasis in Rice.

Unraveling the mechanisms behind plant growth and immunity contributes to effective crop improvement. Membrane attack complex/perforin (MACPF) domain proteins play vital roles in innate and adaptive immunity in vertebrates; however, their molecular functions in plants remain largely unexplored. Here, we isolated and characterized a rice mutant, Oryza sativa constitutively activated cell death 1 (oscad1), which exhibited a lesion mimic phenotype and growth inhibition with increased cell death, elevated ROS accumulation, and enhanced resistance to bacterial blight Xanthomonas oryzae pv.

Oxidative stress of mitophagy in neurodegenerative diseases: Mechanism and potential therapeutic targets.

Neurodegenerative diseases are now significant chronic progressive neurological conditions that affect individuals' physical health. Oxidative stress is crucial in the development of these diseases. Among the various neurodegenerative diseases, mitochondrial damage has become a major factor in oxidative stress and disease advancement.

Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice.

The use of antibiotics is the preferred therapy for bacterial diseases. However, overusing antibiotics has led to the development of antibiotic resistance in bacteria, which is now a major public health concern. Therefore, in this study, the performance of lysozyme (LYZ)/tracheal antimicrobial peptide (TAP)-based tissue-specific expression antimicrobial plasmids (TSEAP) have been evaluated in the treatment of mastitis in mice.

Lanthanide binding peptide surfactants at air-aqueous interfaces for interfacial separation of rare earth elements.

Rare earth elements (REEs) are critical materials to modern technologies. They are obtained by selective separation from mining feedstocks consisting of mixtures of their trivalent cation. We are developing an all-aqueous, bioinspired, interfacial separation using peptides as amphiphilic molecular extractants.

Differential effects of systemic immune inflammation indices on hepatic steatosis and hepatic fibrosis: evidence from NHANES 1999-2018.

Background: Several studies have demonstrated that systemic immune inflammation index (SII) has a positive relationship with hepatic steatosis. However, it is lack of system evidence for the correlation between SII and hepatic fibrosis. The objective of this study was to evaluate the relationships between SII and hepatic steatosis or hepatic fibrosis.