Impact of interventions on mpox transmission during the 2022 outbreak in Canada: a mathematical modeling study of three different cities.

Objectives: The global mpox (clade II) outbreak of 2022 primarily affected gay, bisexual, and other men who have sex with men (GBM) and was met with swift community and public health responses. We aimed to estimate the relative impact of changes in sexual behaviours, contact tracing/isolation, and first-dose vaccination on transmission in Canadian cities.

Methods: We estimated changes in sexual behaviours during the outbreak using 2022 data from the Engage Cohort Study which recruited self-identified GBM in Montréal, Toronto, and Vancouver (n=1,445).

Would the utilization of sFlt-1/PlGF ratio in clinical practice prevent unnecessary hospital admissions of cases with preeclampsia?

Objectives: Preeclampsia (PET) is a serious pregnancy complication with potential adverse maternal and fetal outcomes. Recent research has examined the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio for predicting PET. The study aimed to assess the efficacy of the sFlt-1/PlGF ratio in ruling out unnecessary hospital admission and PET.

Compressive behavior of elliptical concrete-filled steel tubular short columns using numerical investigation and machine learning techniques.

This paper presents a non-linear finite element model (FEM) to predict the load-carrying capacity of three different configurations of elliptical concrete-filled steel tubular (CFST) short columns: double steel tubes with sandwich concrete (CFDST), double steel tubes with sandwich concrete and concrete inside the inner steel tube, and a single outer steel tube with sandwich concrete. Then, a parametric and analytical study was performed to explore the influence of geometric and material parameters on the load-carrying capacity of elliptical CFST short columns. Furthermore, the current study investigates the effectiveness of machine learning (ML) techniques in predicting the load-carrying capacity of elliptical CFST short columns.

Emerging insights: miRNA modulation of ferroptosis pathways in lung cancer.

The newly discovered programmed iron-dependent necrosis, ferroptosis, is a novel pathway that is controlled by iron-dependent lipid peroxidation and cellular redox changes. It can be triggered intrinsically by low antioxidant enzyme activity or extrinsically by blocking amino acid transporters or activating iron transporters. The induction of ferroptosis involves the activation of specific proteins, suppression of transporters, and increased endoplasmic reticulum (ER) stress (a condition in which the ER, a crucial organelle involved in protein folding and processing, becomes overwhelmed by an accumulation of misfolded or unfolded proteins.