The effect of Zexie decoction on vestibular and auditory function in DDAVP-induced endolymphatic hydrops of Guinea pigs.

Objective: To investigate the effects of Zexie decoction on vestibular and auditory function in guinea pigs with endolymphatic hydrolysis induced by desmopressin. Methods: Sixty guinea pigs were randomly and evenly divided into four groups, each group has 15 guinea pigs: normal control group, DDAVP group, DDAVP modeling combined with Zexie Decoction group, and DDAVP combined with Double Zexie group. At 7 and 14 days, bone-conducted cervical vestibular evoked myogenic potential tests, auditory brainstem responses, and distortion-product otoacoustic emissions were conducted on each group of guinea pigs to evaluate their vestibular and auditory function quantitatively.

Integrated Microfluidic Chip for Neutrophil Extracellular Vesicle Analysis and Gastric Cancer Diagnosis.

Neutrophil-derived extracellular vesicles (NEVs) are critically involved in disease progression and are considered potential biomarkers. However, the tedious processes of NEV separation and detection restrain their use. Herein, we presented an integrated microfluidic chip for NEV (IMCN) analysis, which achieved immune-separation of CD66b NEVs and multiplexed detection of their contained miRNAs (termed NEV signatures) by using 10 μL serum samples.

High-uniformity, low-cost, ultra-dense arrays of Au-capped plastic nanopillars fabricated via nanoimprint lithography as reliable SERS substrates.

Nanoimprint lithography (NIL) is gradually becoming a powerful tool for the fabrication of periodic nanostructures. This method can offer a more cost-effective solution for large-scale manufacturing compared to methods that only rely on deep ultraviolet (DUV) immersion, since the product of DUV immersion can be utilized as a Si mold to fabricate a reusable plastic stamp mold. In this work, arrays of plastic nanopillars coated with nanostructured gold film exhibiting ultra density prepared through NIL and Au sputtering are successfully developed.

Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with unresectable hepatocellular carcinoma.

Background: The role of systemic tumor immune environment (STIE) is unclear in hepatocellular carcinoma (HCC). This study aimed to exam the cells in the STIE, their changes after transarterial chemoembolisation (TACE), stereotactic body radiotherapy (SBRT), and immunotherapy (IO) and explore their significance in the treatment response of patients with unresectable HCC.

Methods: This is a prospective biomarker study of patients with unresectable HCC.