Metabolome modification and underlying biomarker of noise-induced hearing loss Guinea pig cochlear fluid.

Background: Noise-induced hearing loss (NIHL) is a kind of acquired sensorineural hearing loss and has shown an increasing incidence in recent years. Hence, elucidating the exact pathophysiological mechanisms and proposing effective treatment and prevention methods become the top priority. Though a great number of researches have been carried out on NIHL, few of them were focused on metabolites.

Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis.

Glioblastoma multiforme (GBM) is characterized by pronounced immune escape and resistance to chemotherapy-induced apoptosis. Preliminary investigations revealed a marked overexpression of gasdermin E (GSDME) in GBM. Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicating the potential as a viable approach of inducing anti-tumor immune activation.

Engineering Subnanometric Electronic Interaction between Ru and Mn in Zeolite Boosts Catalytic Oxidation of Dichloromethane.

Designing catalysts with both activity and stability remains a grand challenge for the removal of chlorinated volatile organic compounds (CVOCs) by catalytic oxidation. Herein, the Ru-Mn subnanometric species encapsulated in ZSM-5 zeolite (RuMn@Z) was synthesized. It shows that the 90% conversion of dichloromethane is as low as 320 °C, which is significantly lower than that of Ru@Z (350 °C) and the impregnation catalyst (RuMn/Z, 355 °C).

Novel Approach for Efficient Separation of Primary Amines Using Supercritical Fluid Chromatography.

Efficient enantioselective separation is a critical process in pharmaceutical and chemical industries for the production of chiral compounds. Herein, we developed a novel approach for the efficient enantioselective separation of primary amines using supercritical fluid chromatography (SFC) with a commercially available SFC column, Cel1. The key factors of separation, including cosolvent ratios, total cosolvent percentages, and temperature, were systematically assessed in this study.

A wearable electrochemical sensor utilizing multifunctional hydrogel for antifouling ascorbic acid quantification in sweat.

The accurate and reliable quantification of the levels of disease markers in human sweat is of significance for health monitoring through wearable sensing technology, but the sensors performed in real sweat always suffer from biofouling that cause performance degradation or even malfunction. We herein developed a wearable antifouling electrochemical sensor based on a novel multifunctional hydrogel for the detection of targets in sweat. The integration of polyethylene glycol (PEG) into the sulfobetaine methacrylate (SBMA) hydrogel results in a robust network structure characterized by abundant hydrophilic groups on its surface, significantly enhancing the PEG-SBMA hydrogel's antifouling and mechanical properties.