Publications by authors named "R William Marks"
Serum amyloid A (SAA) is a key biomarker for diagnosing inflammatory responses in diseases like influenza and COVID-19. An electrochemiluminescence (ECL) biosensor has been constructed for signal enhancement in SAA detection by encapsulating 4,4',4″,4‴-(1,3,6,8-pyrenetetrayl) tetrakis-benzoic acid (TBAPy) into liposomes. Such biomimetic encapsulation shields the biologically important membrane to avoid aggregation of TBAPy and prevents quenching.
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- Advances in imaging techniques now allow for earlier and noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.
- Up to 60% of HCC cases show typical imaging features, while 40% do not, creating challenges for radiologists due to diverse morphologic subtypes and their unique molecular characteristics.
- The article focuses on unusual imaging presentations of HCC and discusses potential diagnostic pitfalls and conditions that may resemble HCC.
Imaging is critical to HCC management, including surveillance, diagnosis, staging, and treatment response assessment, which requires it be performed consistently at a high level. The Liver Imaging Reporting and Data System (LI-RADS) was developed to standardize the acquisition, interpretation, and reporting of liver imaging, but until now, has not addressed the essential component of exam quality and adequacy. In this manuscript, we discuss the concepts of quality and adequacy and their clinical significance in the setting of HCC diagnostic imaging and treatment response assessment.
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- This study introduces a fast and thorough method to screen mushroom extracts for potential bioactive molecules, especially those with antimicrobial properties.
- The method uses bioluminescent bacteria that emit light to indicate various harmful effects caused by the mushroom extracts, such as disrupting bacterial communication and damaging proteins and DNA.
- The approach allows for the simultaneous analysis of many samples and mechanisms of toxicity, significantly speeding up the screening process and revealing the diverse antibacterial effects of the mushroom extracts.
Hybridoma technology remains a cornerstone of monoclonal antibody (mAb) discovery. Classical screening practices such as ELISA, western blot, and dot blot require laborious, time-consuming procedures, rendering them inefficient in time-restricted decision-making. Additionally, due to these assays' practical and technical limitations, specificity testing of the mAbs is usually omitted during the primary screening of hybridoma libraries.
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