Publications by authors named "R Wiggenraad"
Article Synopsis
- The study focuses on validating the updated Lung-molGPA prognostic model to predict survival in patients with brain metastases from non-small cell lung cancer after treatment with stereotactic radiotherapy.
- A total of 241 patients were analyzed using various prognostic factors to assess their survival rates through statistical methods like Kaplan-Meier analysis and Cox proportional hazard model.
- Results showed that while the Lung-molGPA accurately predicted survival in most patient groups, it slightly overestimated survival for patients in the most favorable prognostic category.
Background: Stereotactic radiosurgery (SRS) is a frequently chosen treatment for patients with brain metastases and the number of long-term survivors is increasing. Brain necrosis (e.g.
View Article and Find Full Text PDFBackground And Purpose: During radiotherapy treatment planning, avoidance of organs at risk (OARs) is important. An international consensus-based delineation guideline was recently published with 34 OARs in the brain. We developed an MR-based OAR autosegmentation atlas and evaluated its performance compared to manual delineation.
View Article and Find Full Text PDFBackground: Stereotactic radiotherapy (SRT) is an attractive treatment option for patients with brain metastases (BM), sparing healthy brain tissue and likely controlling local tumors. Most previous studies have focused on radiological response or survival. Our randomized trial (NCT02353000) investigated whether quality of life (QoL) is better preserved using SRT than whole-brain radiotherapy (WBRT) for patients with multiple BM.
View Article and Find Full Text PDFThe purpose was to compare linac-based stereotactic radiosurgery and hypofractionated radiotherapy plan quality of automated planning, intensity modulated radiotherapy (IMRT) and manual dynamic conformal arc (DCA) plans as well as single- and multiple-isocenter techniques for multiple brain metastases (BM). For twelve patients with four to ten BM, seven non-coplanar linac-based plans were created: a manually planned DCA plan with a separate isocenter for each metastasis, a single-isocenter dynamic IMRT plan, an automatically generated single-isocenter volumetric modulated arc radiotherapy (VMAT) plan, four automatically generated single-isocenter DCA plans with three or five couch angles, with high or low sparing of normal tissue. Paddick conformity index, gradient index (GI), mean dose, total V and V of uninvolved brain, number of monitor units (MUs), irradiation time and pass rate were compared.
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