Lessons from the pandemic: An innovative scheme to support research in the North West Coast.

In 2021, a Clinical Research Fellow (CRF) scheme was created to serve the North West Coast (NWC) region in line with the key health priorities set out by the Clinical Research Network. Five doctors in pre-specialist training were placed in NHS trust research departments across the NWC. The scheme aimed to provide early career research experience while also enhancing the provision of research across the region.

Ground Validation Reveals Limited Applicability of Species Distribution Models for Dakota Skipper (Hesperia dacotae, Lepidoptera: Hesperiidae) Recovery Efforts in Canada.

Species distribution models (SDMs) use spatial relationships between species occurrence and habitat (predictor) variables to generate maps of habitat suitability across a region of interest. These maps are frequently used in recovery planning efforts for endangered species, but they are influenced by data availability, selection of predictor variables, and choice of model type. Ground validation is necessary to robustly evaluate map accuracy, but it is rarely done, making it difficult to determine which modeling approach is best-suited for a given species or region.

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.

Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple AML subtypes. One common factor across AML subtypes is the presence of a block in differentiation.