Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10) and confirmed previously reported associations for 27 risk regions. Conditional analyses identified an additional 11 signals independent of the primary signal at six risk regions (p value <10).

Qualitative and Economic Impact of Standardized and Digitalized Operation Room Processes in Obesity Surgery.

Purpose: The introduction of innovative digital solutions in healthcare lags compared to other industries but promises high potential to create value in efficiency and quality. Increasing economic pressure forces hospitals to optimize operating room (OR) processes, in which such solutions might provide additional support.

Materials And Methods: This retrospective case-control and monocentric study investigated if digitalized and standardized intraoperative surgical workflows of laparoscopic Roux-en-Y gastric bypass (LRYGB) have a significant impact on efficiency, quality, and economics.

Effects of Acquisition Matrix Size on the Accuracy and Repeatability of Parameters of Left Ventricular Function: A Phantom Study for ECG-gated Myocardial SPECT.

: The voxel size in ECG-gated myocardial SPECT (GSPECT) is a compromise between geometric resolution and count statistics with varying values and is rather inconsistent in different centers. We investigated the influence of typical acquisition matrix sizes for GSPECT on the reproducibility and accuracy of left ventricular function parameters using a dynamic heart phantom. : Ten paired acquisitions, each pair with slightly different phantom positions, were obtained using identical imaging parameters except acquisition matrix: 128 × 128 matrix (3.

Correction to: The effect of beta blocker withdrawal on adenosine myocardial perfusion imaging.

Regrettably the original version of the above article contained errors in Table 2 and wrong values in the text. The corrected table is presented here and the values which have been corrected now appear in bold text. Page 1223 abstract Global MBF showed an increase from 180.

Utilization of Minimally Invasive Surgery in Endometrial Cancer Care: A Quality and Cost Disparity.

Objective: To describe case mix-adjusted hospital level utilization of minimally invasive surgery for hysterectomy in the treatment of early-stage endometrial cancer.

Methods: In this retrospective cohort study, we analyzed the proportion of patients who had a minimally invasive compared with open hysterectomy for nonmetastatic endometrial cancer using the U.S.