New Measurement of the 60Fe Half-Life.

We have made a new determination of the half-life of the radioactive isotope 60Fe using high precision measurements of the number of 60Fe atoms and their activity in a sample containing over 10(15) 60Fe atoms. Our new value for the half-life of 60Fe is (2.62+/-0.

Precision measurement of the 7Be(p,gamma)8B cross section with an implanted 7Be target.

The 7Be(p,gamma)8B reaction plays a central role in the evaluation of solar neutrino fluxes. We report on a new precision measurement of the cross section of this reaction, following our previous experiment with an implanted 7Be target, a raster-scanned beam, and the elimination of the backscattering loss. The new measurement incorporates a more abundant 7Be target and a number of improvements in design and procedure.

PET imaging drug distribution after intratumoral injection: the case for (124)I-iododeoxyuridine in malignant gliomas.

Unlabelled: Locoregional administration may yield higher tumor drug concentrations compared with intravenous injection and may reduce the risk of systemic adverse effect. Furthermore, in the case of brain tumors, it may circumvent limited drug delivery imposed by the blood-brain barrier. We used PET to study the retention and spatial distribution of iododeoxyuridine (IUdR), which has been used as a DNA-targeting radiosensitizing drug and which can be charged with therapeutic nuclides.

Synthesis of an o-Carboranyl Derivative of 4-[5-(4-Methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazol-2'-yl]phenol.

Synthesis of an o-carboranyl derivative of 4-[5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazol-2'-yl]phenol (1), a candidate for application in boron neutron capture therapy for cancer treatment, is described. Decaborane was introduced into 3-(p-cyanophenoxy)-1-propyne (11) to form 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane(12) (12), which was transformed into the corresponding imidate 10 in order to be coupled with 4-cyano-o-phenylenediamine (13) to give 1-[4-(5'-cyano-1H-benzimidazol-2'-yl)phenoxymethyl]-1,2-dicarba-closo-dodecaborane(12) (14). The latter was reacted to the related imidate salt 15 and condensed with 5-(4-methyl-1-piperazinyl)-o-phenylenediamine (6) to the title compound 1-{4-[5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazol-2'-yl]phenoxymethyl}-1,2-dicarba-closo-dodecaborane(12) (2).

Preparation of 124I solutions after thermodistillation of irradiated 124TeO2 targets.

The 4.15-d radionuclide 124I is produced via the nuclear reaction 124Te(d, 2n) 124I by irradiation of 96% enriched 124TeO2 with 14 MeV deuterons, followed by thermodistillation. In order to minimise the loss of 124I, the quartz distillation tube was fitted to a stainless steel helix capillary trap directly behind the end of the furnace.