Publications by authors named "R Wall"
Article Synopsis
- This study investigates the effects of vitamin C and hydrocortisone on pediatric sepsis, aiming to improve survival rates without the need for inotropes/vasopressors.
- The RESPOND trial is a randomized, open-label study involving nine PICUs in Australia and New Zealand, focusing on children under 18 with suspected or confirmed sepsis.
- It will assess outcomes such as time alive without inotropic support, mortality rates, and quality of life, involving 384 patients to generate robust data for better treatment strategies.
Article Synopsis
- Tuberculosis (TB) is a major global health issue, with ongoing research aimed at developing new anti-TB medications that effectively target the disease.
- Scientists created an open-access database containing genetic variations from over 50,000 clinical TB isolates to help understand resistance mutations seen in real-world scenarios.
- The analysis of this database showed how specific genetic variations relate to drug resistance and the importance of genetic diversity in drug targets, making it a useful tool for drug discovery and development.
Article Synopsis
- - The study investigates how to determine the feeding status of Ixodes ricinus ticks by using a morphological ratio called the "hunger index," which could help understand tick population dynamics without harming the ticks.
- - Researchers collected 300 ticks, starved them under controlled conditions, and measured changes in their morphology and stored lipids every two weeks.
- - Results showed that while both the hunger index and stored lipid levels changed with starvation and were positively correlated, the morphological changes were minimal (11%) and highly variable, indicating that this method may only provide a rough estimate of hunger status in field conditions.
Article Synopsis
- - The EXACT trial, sponsored by the National Cancer Institute, aims to evaluate whether 150 minutes of weekly moderate-intensity aerobic exercise can lower systemic inflammation in stage I-III colorectal cancer survivors compared to a control group over 12 weeks.
- - Recruitment for the study involved inviting over 3,000 survivors, with 89 screened and 60 randomized, revealing that younger age, female sex, and certain racial and clinical factors positively influenced participation.
- - Findings showed high exercise adherence at 92.2%, with all participants meeting the 80% adherence goal, and the trial will provide insights into how exercise may help prevent cancer recurrence and improve survival rates.
Although genome-wide polycistronic transcription places major emphasis on post-transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslated regions (UTRs) have remained largely uncharacterised. Here, we describe a genome-scale massive parallel reporter assay coupled with 3'-UTR-seq profiling in the African trypanosome and identify thousands of regulatory UTRs. Increased translation efficiency was associated with dosage of adenine-rich poly-purine tracts (pPuTs).
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