Homologous Recombination Deficiency and Cyclin E1 Amplification Are Correlated with Immune Cell Infiltration and Survival in High-Grade Serous Ovarian Cancer.

Background: How molecular profiles are associated with tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC) is incompletely understood. Therefore, we analyzed the TME and molecular profiles of HGSOC and assessed their associations with overall survival (OS).

Methods: Patients with advanced-stage HGSOC treated in three Dutch hospitals between 2008-2015 were included.

Family Complexity and Parents' Migration: The Role of Repartnering and Distance to Non-Resident Children.

Recent research suggests that the increasing complexity of family life could be a factor in declines in internal migration (long-distance moves within countries). As many separated parents continue to share childcare responsibilities or have visiting arrangements, their mobility is naturally constrained. However, the relationship between family complexity and individual migration behaviour has never been studied explicitly.

Tumour-infiltrating lymphocytes (TILs) and BRCA-like status in stage III breast cancer patients randomised to adjuvant intensified platinum-based chemotherapy versus conventional chemotherapy.

Background: The prognostic value of tumour-infiltrating lymphocytes (TILs) differs by breast cancer (BC) subtype. The aim of this study was to evaluate TILs in stage III BC in the context of BRCA1/2-like phenotypes and association with outcome and benefit of intensified platinum-based chemotherapy.

Patients And Methods: Patients participated in a randomised controlled trial of adjuvant intensified platinum-based chemotherapy versus conventional anthracycline-based chemotherapy carried out between 1993 and 1999 in stage III BC.

Challenging perceptions of disciplinary divide: an ethnographer's experience of collegiality, collaboration and crisis.

Warned by social scientists about 'the disciplinary divide' and the hostility of medical professionals to qualitative research, I was pleasantly surprised by the collegiality I experienced while conducting fieldwork among clinician-researchers in South Africa. This commentary is a challenge to common discourse, historically dominant in a global (north) anthropology, that biomedical practitioners are necessarily antagonistic to the humanities. Drawing on my field experiences, I propose an optimistic outlook for collaboration and inclusivity in developing medical and health humanities in Africa.

Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.

DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first line defense against alkylating and platinating chemotherapeutics. Effective DDT strongly depends on damage-induced, site-specific PCNA-ubiquitination at Lysine (K) 164 by the E2/E3 complex (RAD6/18).