Publications by authors named "R W W Peeling"
Article Synopsis
- A new two-level hierarchical framework called FESSA is introduced to assess sustainability at the early stages of process or product development.
- The framework is combined with an enhanced decision-making method (WSM-MCDA) to handle situations with uncertainty, demonstrated through a case study in specialty polymer manufacturing.
- This approach helps innovation managers make informed decisions despite the high uncertainty and knowledge gaps typical in the early innovation cycle, offering a more effective evaluation method (CURE WSM-MCDA) than traditional approaches without requiring extensive computations.
Background: Mobile health interventions like telephone hotlines face challenges that may threaten their use, adoption and sustainability in Africa.
Aim: We sought to understand the barriers and facilitators for sustainability of telephone hotlines used in infectious disease outbreaks in Africa using a scoping review and a qualitative study.
Setting: Participants form 12 African countries and Database searches.
Background: Southern African countries have the largest global burden of HIV and syphilis, with a high prevalence among women of reproductive age. Although antenatal screening is standard of care, syphilis screening has generally lagged behind HIV screening. We aimed to evaluate the performance and operational characteristics of two commercial dual HIV/syphilis point-of-care tests (POCTs) for simultaneous maternal HIV/syphilis screening.
View Article and Find Full Text PDFStandardised protocol for a prospective international multicentre clinical-based evaluation of point-of-care tests for the screening of genital and extragenital chlamydial and gonococcal infections in men who have sex with men and for the screening of genital chlamydial, gonococcal and infections in at risk women.
BMJ Open
June 2024
Article Synopsis
- In 2016, the WHO reported approximately 374 million new infections from four curable STIs: chlamydia, gonorrhoea, syphilis, and trichomoniasis, highlighting the need for effective screening methods.
- Recent advancements in point-of-care tests (POCTs) for these STIs show promising results in lab studies, but there is a lack of clinical performance data, particularly among high-risk groups like men who have sex with men (MSM) and women.
- This research aims to evaluate the effectiveness and user acceptability of molecular-based diagnostic tests (Xpert CT/NG and Xpert TV) for detecting these infections in MSM and women across seven countries, comparing results to established reference tests.
Article Synopsis
- Improving access to tuberculosis testing is crucial to combat the disease, as a significant number of cases go undiagnosed despite advances in rapid diagnostics.
- Over 3.1 million out of an estimated 10.6 million global tuberculosis cases in 2022 were not diagnosed, highlighting a major gap that improvements in test accuracy alone cannot close.
- Diagnostic yield, the efficacy of tests in identifying tuberculosis in various populations, especially those who can't produce sputum, must be prioritized in test evaluations to enhance effective coverage and improve overall clinical care.