Osteochondritis Dissecans of the Capitellum: Influence of Activity on Lesion Location Within a Zone of Propensity.

Background: There may be an association between repetitive stress on the elbow and capitellar osteochondritis dissecans (COCD). The influence of activity on the characteristics or specific location of the lesion within a capitellar zone of propensity remains unclear.

Purpose/hypothesis: The purpose of this study was to evaluate COCD in gymnasts and baseball players compared with a non-upper extremity (non-UE) sport COCD cohort.

Continuous Glucose Monitor Metrics That Predict Neonatal Adiposity in Early and Later Pregnancy Are Higher in Obesity Despite Macronutrient-Controlled Eucaloric Diets.

Background: Fasting glucose is higher in pregnancies with obesity (OB); less is known about postprandial (PP) and nocturnal patterns when the diet is eucaloric and fixed or about the continuous-glucose-monitor (CGM) metrics that predict neonatal adiposity (NB%fat). We hypothesized that continuous glucose monitors (CGMs) would reveal higher glycemia in OB vs. normal weight (NW) during (14-16 weeks) and (26-28 weeks) gestation despite macronutrient-controlled eucaloric diets and elucidate unique predictors of NB%fat.

Case Studies on Changes and Proposed Process Development Approaches Reflecting Applicability of PDA .

Vaccines are complex and a very diverse group of products with relatively long product life cycles. The manufacturing programs for these vaccines need to be continually updated to comply with evolving regulatory expectations. Members of the Parenteral Drug Association (PDA) Vaccines Interest Group (VIG) authored and published PDA (TR 89), which seeks to provide context to vaccine developers and manufacturers regarding key aspects of new or legacy vaccines such as control strategy from process development to vaccine life cycle management, comparability and life cycle management including technical, validation, quality, and regulatory perspectives.

Two-Year Treatment With Metformin During Puberty Does Not Preserve β-Cell Function in Youth With Obesity.

Context: Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the β-cell.

Objective: Evaluate the impact of metformin treatment during puberty, a critical window of cardiometabolic change, on insulin sensitivity (Si) and compensatory β-cell response in youth with obesity.

Setting: Pediatric academic hospital clinical translational research center.

Dust emission source characterization for visibility hazard assessment on Lordsburg Playa in Southwestern New Mexico, USA.

In drylands around the world, ephemeral lakes (playas) are common. Dry, wind-erodible playa sediments are potent local and regional sources of dust and PM (airborne particles with diameters less than 10 μm). Dust clouds often cause sudden and/or prolonged loss of visibility to travelers on downwind roadways.