Publications by authors named "R W Stidham"
Background: We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.
Methods: Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers.
Article Synopsis
- Ulcerative colitis (UC) is a disease that causes inflammation, making it hard to monitor without invasive procedures like endoscopy; this study explores serum extracellular matrix (ECM) fragments as possible noninvasive indicators of disease severity and treatment effectiveness.
- The research involved 49 UC patients and 50 healthy controls, measuring various ECM biomarkers at three different time points, revealing that certain markers like PRO-C11 and PRO-C3 can effectively predict responses to treatment and differentiate between disease severity levels.
- The findings suggest that serum ECM fragments correlate with endoscopic disease severity and may serve as future therapeutic targets to help prevent intestinal damage in UC patients.
Article Synopsis
- In May 2022, mpox cases started spreading outside their usual areas in Central and West Africa, mostly affecting men who have sex with men (MSM) through sexual networks.
- The Military Health System (MHS) lacked documented data on mpox compared to civilian populations, prompting an investigation into MHS cases through various health reporting and record systems.
- From May 2022 to April 2024, a total of 146 confirmed or probable mpox cases were identified in MHS, primarily in MSM, with most individuals showing classic early symptoms, some also experiencing anogenital and urinary issues.
Artificial intelligence (AI) refers to computer-based methodologies that use data to teach a computer to solve pre-defined tasks; these methods can be applied to identify patterns in large multi-modal data sources. AI applications in inflammatory bowel disease (IBD) includes predicting response to therapy, disease activity scoring of endoscopy, drug discovery, and identifying bowel damage in images. As a complex disease with entangled relationships between genomics, metabolomics, microbiome, and the environment, IBD stands to benefit greatly from methodologies that can handle this complexity.
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