Publications by authors named "R W Siggins"
Adipose-derived stem cells (ADSCs) have an important role in the modulation of burned tissue repair through the release of paracrine factors that stimulate the wound healing response. In this study, we tested the hypothesis that smoking status alters the profile of paracrine factors secreted from ADSCs isolated from damaged adipose tissue. Adipose tissue was collected from adult patients (N=8) with severe burn injuries (>20% total body surface area) at the index operation.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of heparan sulfate 6-O-endosulfatases (Sulf1 and Sulf2) in bone marrow hematopoiesis by using a new mouse model with specific deletion of these enzymes in myeloid cells.
- Male LysM-Sulf knockout mice showed an age-related increase in hematopoietic stem cells and granulocyte-monocyte lineages, but a decrease in lymphoid progenitors and B cells, while red blood cell and platelet production was impaired at later stages.
- The findings highlight age- and sex-dependent differences in hematopoiesis and 6-O-sulfation levels, suggesting that Sulfs play a crucial role in regulating blood cell development in mice.
Early increase in the level of endothelial progenitor cells (EPCs) in the systemic circulation occurs in patients with septic infection/sepsis. The significance and underlying mechanisms of this response remain unclear. This study investigated the bone marrow EPC response in adult mice with septic infection induced by intravenous injection (i.
View Article and Find Full Text PDFArticle Synopsis
- * Mitochondria are important for various cellular functions beyond energy production, such as immune activation and nutrient sensing; however, alcohol impairs their function, leading to the generation of harmful reactive oxygen species (ROS) and accumulation of dysfunctional mitochondria.
- * This review explores how alcohol-induced mitochondrial dysfunction disrupts immunometabolism, both in terms of immune cell influence on tissue metabolism and immune cell energy usage, ultimately contributing to tissue injury.
Article Synopsis
- Antiretroviral therapy has significantly improved life expectancy for people living with HIV (PLWH), but they still face higher risks of age-related health issues, such as frailty.
- A study involving 341 participants found that specific body composition metrics, like fat-free mass and waist-to-hip ratio, are linked to frailty risk, but not all measures had the same impact depending on factors like substance use and physical activity.
- The results indicated that muscle strength and recent alcohol use were important moderators in the relationship between body composition and frailty, with variations based on individual characteristics such as strength levels and body mass index (BMI).