Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.

Management of labor in women with diabetes is challenging due to the high risk of peri- and postpartum complications. To avoid cesarean section and assist with labor progression, Pitocin, a synthetic oxytocin, is frequently used to induce and augment labor. However, the efficacy of Pitocin is often compromised in diabetic pregnancies, leading to increased cesarian delivery.

Social strata and oral pathologies: A comparative study in two co-localized, temporally disjunct burial sites of ancient Egypt.

Background/purpose: Oral pathologies in ancient human remains provide a unique glimpse into the lifestyles, health, and societal norms of past civilizations, including ancient Egypt. However, comprehensive paleo-odontological studies accounting for temporal and sociodemographic variations remain scarce. We address this gap by analyzing oral pathologies in the remains of 68 and 57 adult individuals, respectively, unearthed from two adjacent yet temporally and socioeconomically diverse burial sites, representing the XI dynasty (2160-1985 BCE) and the XXV-XXVI dynasties (948-525 BCE), at Luxor's Thutmose III Funerary Temple.

Progressive cervical cord atrophy parallels cognitive decline in Alzheimer's disease.

Alzheimer's disease (AD) is characterized by progressive episodic memory dysfunction. A prominent hallmark of AD is gradual brain atrophy. Despite extensive research on brain pathology, the understanding of spinal cord pathology in AD and its association with cognitive decline remains understudied.