Publications by authors named "R W Sager"
Deficits in neurogenesis markers in the subependymal zone (SEZ) are associated with elevated inflammation in schizophrenia and bipolar disorder. However, the extent to which complement factors are also changed in the SEZ of these major psychiatric disorders and their impact on neurogenesis remains poorly understood. We extracted RNA from the SEZ of 93 brains, including controls (n = 32), schizophrenia (n = 32), and bipolar disorder (n = 29) cases.
View Article and Find Full Text PDFArticle Synopsis
- PP5 is a protein that regulates hormone and stress signaling as well as apoptosis, featuring both regulatory and catalytic domains which can be modified after translation.
- It has a TPR domain that typically inhibits its activity, but certain activators can relieve this inhibition, allowing PP5 to become active.
- A new method using FC-FRET was developed to observe PP5's conformational changes and activity in live cells, revealing that its activity depends on multiple conformational states and that post-translational modifications significantly influence these changes.
The serine/threonine protein phosphatase 5 (PP5) regulates hormone and stress-induced signaling networks. Unlike other phosphoprotein phosphatases, PP5 contains both regulatory and catalytic domains and is further regulated through post-translational modifications (PTMs). Here we identify that SUMOylation of K430 in the catalytic domain of PP5 regulates phosphatase activity.
View Article and Find Full Text PDFIn this research, we examine whether moral judgments sometimes violate the normative principle of procedure invariance - that is, whether normatively equivalent elicitation tasks can result in different judgment patterns. Specifically, we show that the relative morality of two actions can reverse across evaluation modes and elicitation tasks, mirroring preference reversals in consumer behavior. Across six studies (five preregistered, total N = 719), we provide evidence of three reversals of moral judgments of sacrificial dilemmas.
View Article and Find Full Text PDFBackground: The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet may slow cognitive decline in older adults. A potential mechanism could be possible anti-inflammatory properties of the MIND-diet.
Objective: To examine whether adherence to the MIND diet at baseline is associated with the odds of mild cognitive impairment (MCI) and changes in biomarkers of inflammation (High-sensitivity C-reactive Protein(hsCRP), interleukin-6(IL-6)) over three years in adults ≥70 years.