Publications by authors named "R W STANFORD"
Objectives: To develop and user-test a patient decision aid providing evidence-based information for people with chronic low back pain (LBP) and degenerative disc disease considering lumbar fusion.
Design: Convergent parallel mixed methods study.
Setting: A prototype patient decision aid was developed, guided by the International Patient Decision Aid Standards (IPDAS) criteria, a multidisciplinary steering committee, and insights from previous studies.
Objective: To describe the demographic/clinical characteristics, treatment patterns, and mortality among patients hospitalized with COVID-19 during Omicron predominance by immunocompromised and high-risk status.
Methods: Retrospective observational study of patients hospitalized with COVID-19 between January 1, 2022 and November 30, 2022, using data from the Optum de-identified Clinformatics Data Mart Database. Patient demographic/clinical characteristics, treatments, mortality and costs, were assessed, during the emergence of BA.
Article Synopsis
- International guidelines recommend keeping mean arterial pressure (MAP) above 85 mmHg for spinal cord perfusion after traumatic injuries, but variations in blood pressure management practices were found in NSW's emergency departments and could exist in ICUs.
- A study examined blood pressure management in two referral centers in NSW, involving 98 acute SCI patients, where a significant number required vasopressors and had notable complications.
- Results showed that average MAP targets were lower than recommended, with many patients experiencing low systolic blood pressure and longer ICU stays associated with MAP target management.
Article Synopsis
- There are various surgical options for treating degenerative lumbar spinal stenosis (LSS), but current guidelines don't specify which should be prioritized due to past studies lacking in convincing evidence.
- A systematic review included 43 randomized controlled trials (RCTs) with over 5,000 participants, evaluating different surgical interventions, focusing on their impacts on physical function and adverse events.
- Results showed that endoscopic-assisted laminotomy and laminectomy with Coflex had small effects on physical function in the short term, while longer-term outcomes were varied, with some surgeries linked to fewer adverse effects compared to traditional laminectomy.
Background: In the United States, dupilumab is approved for moderate-to-severe eosinophilic or oral corticosteroid-dependent asthma, and omalizumab is approved for managing moderate-to-severe allergic asthma uncontrolled by inhaled corticosteroids. However, limited comparative effectiveness data exist for these biologics due to differing patient characteristics and treatment histories.
Objective: This study assessed the real-world effectiveness of dupilumab and omalizumab for asthma in patients in the United States.