Publications by authors named "R W Redline"

Article Synopsis
  • - The study aimed to explore how placental abnormalities affect the neurodevelopmental outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia, hypothesizing that acute placental issues would lower risks of death or developmental impairments by age 2.
  • - Out of 500 newborns with severe HIE, 321 had their placental pathology examined, revealing various types of abnormalities; however, the risk of negative outcomes between those with and without acute placental issues did not show a significant difference.
  • - The conclusion indicates that while placental abnormalities did not show a clear link to death or neurodevelopmental impairment in HIE cases, the potential connection between multiple chronic
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Pathologic examination of the placenta can provide insight into likely (and unlikely) causes of antepartum and intrapartum events, diagnoses with urgent clinical relevance, prognostic information for mother and infant, support for practice evaluation and improvement, and insight into advancing the sciences of obstetrics and neonatology. Although it is true that not all placentas require pathologic examination (although alternative opinions have been expressed), prioritization of placentas for pathologic examination should be based on vetted indications such as maternal comorbidities or pregnancy complications in which placental pathology is thought to be useful for maternal or infant care, understanding pathophysiology, or practice modifications. Herein we provide placental triage criteria for the obstetrical and neonatal provider based on publications and expert opinion of 16 placental pathologists and a pathologists' assistant, formulated using a modified Delphi approach.

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The importance of a fully functioning placenta for a good pregnancy outcome is unquestioned. Loss of function can lead to pregnancy complications and is often detected by a thorough placental pathologic examination. Placental pathology has advanced the science and practice of obstetrics and neonatal-perinatal medicine by classifying diseases according to underlying biology and specific patterns of injury.

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