Publications by authors named "R W Ramsay"
Article Synopsis
- - Cancers of the central nervous system (CNS) have a unique microenvironment influenced by immune-privilege and interactions between neural, immune, and cancer cells, which form complex communication networks.
- - This cellular crosstalk mimics normal physiological functions and plays a key role in tumor progression through specific signaling pathways and transcription programs.
- - At the center of these regulatory processes is the CREB protein, a key transcriptional factor that influences crucial CNS activities like neurogenesis and memory, and is also exploited by CNS tumors for their development and function.
Purpose: Whilst the treatment paradigm for colorectal cancer has evolved significantly over time, there is still a lack of reliable biomarkers of treatment response. Treatment decisions are based on high-risk features such as advanced TNM stage and histology. The role of the tumour microenvironment, which can influence tumour progression and treatment response, has generated considerable interest.
View Article and Find Full Text PDFAdoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts.
View Article and Find Full Text PDFObjectives: To describe acute seizure treatment for the long-term care setting, emphasizing rescue (acute abortive) medications for on-site management of acute unexpected seizures and seizure clusters.
Design: Narrative review.
Setting And Participants: People with seizures in long-term care, including group residences.