Fecal Microbiota Transplantation (FMT) From a Human at Low Risk for Alzheimer's Disease Improves Short-Term Recognition Memory and Increases Neuroinflammation in a 3xTg AD Mouse Model.

Human microbiota-associated murine models, using fecal microbiota transplantation (FMT) from human donors, help explore the microbiome's role in diseases like Alzheimer's disease (AD). This study examines how gut bacteria from donors with protective factors against AD influence behavior and brain pathology in an AD mouse model. Female 3xTgAD mice received weekly FMT for 2 months from (i) an 80-year-old AD patient (AD-FMT), (ii) a cognitively healthy 73-year-old with the protective APOEe2 allele (APOEe2-FMT), (iii) a 22-year-old healthy donor (Young-FMT), and (iv) untreated mice (Mice-FMT).

Unprecedented East Siberian wildfires intensify Arctic snow darkening through enhanced poleward transport of black carbon.

Summer Arctic black carbon (BC) predominantly originates from boreal wildfires, significantly contributing to Arctic warming. This study examined the impact of MODIS-detected extensive East Siberian wildfires from 2019 to 2021 on Arctic BC and the associated radiative effects using GEOS-Chem and SNICAR simulations. During these years, Arctic surface BC aerosol concentrations rose to 46 ng m, 43 ng m, and 59 ng m, nearly doubling levels from the low-fire year of 2022.

Inpatient total thyroidectomy costs and outcomes vary regionally: A nationwide study.

Objectives: While it is known that surgical costs continue to rise in the United States, there is little information about the specific underlying factors for this variation in many common procedures. This study investigates the influence of geographic location and hospital demographics on hospital cost and postoperative outcomes in adult patients undergoing total thyroidectomy (TT).

Methods: The National Inpatient Sample was queried for patients who underwent primary TT between 2016 and 2017.

Role of factors controlling diurnal variation of cold-season formaldehyde during Satellite Integrated Joint Monitoring of Air Quality 2021 campaign.

Formaldehyde (HCHO), a major carbonyl compound in urban air, poses health risks due to its carcinogenic properties. However, the role of FT-PBL exchange in HCHO and the importance of vertical exchange on diurnal variations in HCHO remain unclear. This study investigated the diurnal variability of HCHO in Seoul's planetary boundary layer (PBL) during cold.