Occupational and recreational noise exposure from indoor arena hockey games.

Occupational and recreational noise exposures were evaluated at two sporting arenas hosting collegiate hockey games (Venue 1) and semi-professional hockey (Venue 2). A total of 54 personal noise dosimetry samples were taken over the course of seven home hockey games: 15 workers and 9 fans at Venue 1, and 19 workers and 11 fans at Venue 2. None of the sampled workers were overexposed to noise based on Occupational Safety and Health Administration criteria.

Noise exposure, characterization, and comparison of three football stadiums.

Personal noise exposure samples were collected from five workers at a large-sized college football stadium and five workers at a medium-sized college football stadium in northern Colorado during three home football games, for a total of 30 personal noise exposures. In addition, personal noise exposure samples were collected from five fans at a National Football League (NFL) stadium, and from two fans at each of the college stadiums during three home football games, for a total of 27 personal noise exposure samples. None of the workers' noise doses were above the Occupational Safety and Health Administration (OSHA) permissible exposure limit of 90 dBA.

Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.

Hemoglobin (Hb)-based oxygen carriers (HBOCs) are being developed as a potential therapy for increasing tissue oxygenation, yet they have not reached their full potential because of unwanted hemodynamic side effects (vasoconstriction, low cardiac output, and oxygen delivery) due in part to nitric oxide (NO) scavenging by cell-free Hb. It may be possible to overcome the NO scavenging effect by coinfusing S-nitrosylated (SNO) HBOC along with unmodified HBOC. SNO-HBOC, like free Hb, may act as an NO donor in low-oxygen conditions.

Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition.

Objective: Hemoglobin-based oxygen carriers (HBOC) of several types scavenge nitric oxide from the vasculature resulting in vasoconstriction and hypertension, both systemic and pulmonary. Phosphodiesterase-5 (PDE5) inhibitors promote nitric oxide activity and enhance vasodilation. The purpose of this study was to determine whether combined therapy of glutaraldehyde-polymerized bovine hemoglobin (HBOC) with a PDE5 inhibitor would counter the negative hemodynamic consequences of HBOC therapy alone, resulting in improved hemodynamics and oxygen delivery.

Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat.

Hemoglobin-based oxygen carriers (HBOC) have been primarily studied for blood loss treatment. More recently infusions of HBOC in euvolemic subjects have been proposed for a wide variety of potential therapies in which increased tissue oxygenation would be beneficial. However, compared with the exchange transfusion models to study blood loss, less is known about HBOC oxygen delivery and vasoacitvity when it is infused in euvolemic subjects.