Publications by authors named "R W Glaser"
A biosimilar clinical development program generally includes a pharmacokinetic similarity study and a comparative clinical study. Since both types of studies assess safety and immunogenicity, it is important to evaluate the role of each in determining whether there are any meaningful differences between the proposed biosimilar products and the reference products. We conducted a systematic review and meta-analysis of the safety and immunogenicity data from pharmacokinetic similarity studies and comparative clinical studies, using a database of approved monoclonal antibody and fusion protein biosimilars.
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- Researchers are exploring keratinocytes (KCs) from patients with atopic dermatitis (AD) to study inflammatory responses, suggesting they may better represent AD conditions than KCs from healthy individuals.
- * The study found that KCs from AD patients showed greater expression of AD-related markers when stimulated with cytokines IL-4 and IL-13 compared to those from healthy donors.
- * Hair follicle-derived KCs from AD patients provide a promising noninvasive model for understanding AD-related inflammation and can mimic the disease's features in laboratory setups.
["Red flags" during pregnancy-skin symptoms and their causes during pregnancy].
Dermatologie (Heidelb)
November 2024
Article Synopsis
- - Pregnancy causes significant physical changes in a woman's body, particularly affecting the skin, making it essential for healthcare providers to understand various pregnancy-related skin issues.
- - The article outlines key skin changes during pregnancy, highlighting altered pigmentation and the effects on existing inflammatory skin conditions, including their potential improvement or worsening.
- - It also discusses specific pregnancy dermatoses and the implications of maternal autoimmune diseases on the unborn child, emphasizing the importance of recognizing warning signs or "red flags" for proper diagnosis and care.
Article Synopsis
- About 22% of patients with moderate to severe atopic dermatitis have experienced eczema herpeticum, an infection primarily caused by the herpes simplex virus type 1 (HSV-1), potentially due to reduced antimicrobial peptide activity.
- This study found that the antimicrobial protein RNase 7 can limit HSV-1 infection in human skin cells (keratinocytes) by inhibiting gene expression and viral genome replication without relying on added DNA for stimulation.
- RNase 7 acts on intracellular processes of infection rather than affecting how the virus binds to cells, suggesting that its reduced activity in atopic dermatitis may increase the risk of developing eczema herpeticum.
Commercial SSZ-13 zeolite with different n(Si)/n(Al) ratios and from different suppliers were subjected to a post-synthetic treatment in order to create mesopores of up to 15 nm. Furthermore, the materials were modified with copper ions and thoroughly physico-chemically characterized. The modified textural properties varied the nature of copper species, and thus, activity in the selective catalytic reduction of NO with ammonia (NH-SCR-DeNO).
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