Publications by authors named "R W GERARD"
Article Synopsis
- - Coagulase-negative staphylococci (CONS) are a leading cause of late-onset sepsis in preterm infants, and this study investigates the effectiveness of continuous versus intermittent vancomycin infusion in treating these infections.
- - The study looked at 110 neonates, showing that those on continuous infusion had significantly lower treatment failure rates (17% vs. 44%) and achieved therapeutic drug levels more frequently than those on intermittent infusion.
- - The findings suggest that using adjusted continuous vancomycin infusion might be safer and more effective for treating CONS bacteremia in neonates, but further research is necessary to confirm these results due to the study's observational nature.
The intimate relationship between the epithelium and immune system is crucial for maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease and cancer. Whereas stem cell-derived organoids are powerful models of epithelial function, they lack tissue-resident immune cells that are essential for capturing organ-level processes. We describe human intestinal immuno-organoids (IIOs), formed through self-organization of epithelial organoids and autologous tissue-resident memory T (T) cells, a portion of which integrate within the epithelium and continuously survey the barrier.
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- The study focuses on evaluating the effectiveness of serum galactomannan (GM) testing for diagnosing invasive aspergillosis (IA) in children with cancer, as previous research mainly involves adults.
- Conducted at the University Hospital of Bordeaux, the study observed a low prevalence of IA among high-risk pediatric patients and found that the GM test had poor sensitivity and positive predictive value (PPV), especially when patients were on antifungal prophylaxis.
- The authors suggest that rather than routine screening, testing should be focused on the highest-risk patients, and combining GM with other diagnostic methods like Aspergillus PCR might improve accuracy.
Background: Crohn's disease (CD) is a progressive, destructive, and disabling disorder. Our study aimed to assess changes over time in the Lémann index (LI) and the Inflammatory Bowel Disease Disability Index (IBD-DI) in a cohort of CD patients.
Methods: This was a single-center prospective cohort study of 130 consecutive CD patients with a follow-up of at least 4 years.