Multiple cutaneous mast cell tumors displaying epitheliotropism in a male cat.

A 16-year-old castrated male domestic medium-hair cat was referred for examination of multiple cutaneous mast cell tumors displaying epitheliotropism. Staging tests were negative for distant metastasis. Toceranib phosphate therapy was initiated.

Review of Emotion Regulation in Late Life Mood Disorders.

Emotion regulation (ER), or the ability to modulate the experience and expression of emotion, is critical to adaptive functioning and is a key feature of mood disorders. At the same time, normal aging is associated with changes in ER, though the interaction of aging with the presence of a mood disorder are unclear. Here, we review what is known about ER and its underlying neural mechanisms in late life mood disorders, specifically late life depression and bipolar disorder.

Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization.

Extracellular matrix (ECM) stiffness influences cancer cell fate by altering gene expression. Previous studies suggest that stiffness-induced nuclear deformation may regulate gene expression through YAP nuclear localization. We investigated the role of the nuclear lamina in this process.

Evaluation and Comparison of Tolerance of Ambiguity in Veterinary Pathology Professionals and Trainees.

Ambiguity is ubiquitous in veterinary medicine, including in clinical and anatomic pathology. Tolerance of ambiguity (TOA) relates to how individuals navigate uncertainty. It is associated with psychological well-being in health professionals yet has been little investigated in veterinarians or veterinary pathologists.