Publications by authors named "R W Curry"
Article Synopsis
- Malignant glioma, a deadly brain cancer, creates an immunosuppressive environment that limits the effectiveness of treatments targeting the immune system.
- Researchers used single-cell RNA sequencing to identify glioma cells expressing CD83, a marker linked to mature immune cells, and studied its effects on tumor growth and immune response in mice and human samples.
- Findings indicate that CD83+ tumor cells may promote anti-tumor activity by enhancing T cell responses and increasing inflammatory signals, suggesting that CD83 could be a potential target for improving immunotherapy in glioma patients.
Novel introductions of largemouth bass, Micropterus salmoides, often cause negative impacts on endemic populations of prey fishes and interspecific competitors. Although many studies have investigated trophic interactions between M. salmoides and smallmouth bass, Micropterus dolomieu, few have included chain pickerel, Esox niger, as a competitor despite similarities in their habitat use.
View Article and Find Full Text PDFPurpose: BXQ-350, a nanovesicle formulation of saposin C, is an allosteric sphingolipid metabolism regulator that increases proapoptotic ceramide and decreases oncogenic sphingosine-1-phosphate levels. We conducted a first-in-human phase I study of BXQ-350.
Patients And Methods: Adults (≥18 years old) with advanced/recurrent, treatment-refractory solid tumors or high-grade gliomas received BXQ-350 intravenously in five dose cohorts (0.
Article Synopsis
- Prior research highlighted the complex interaction between glioma cells and neurons, but the unique electrical properties of glioma cells were not well understood.
- Using Patch-sequencing (Patch-seq) on human glioma specimens, researchers found that about one-third of the glioma cells showed characteristics of both neurons and glial cells in IDH mutant tumors.
- A new computational tool called SCRAM helped to identify these hybrid cells, highlighting that they share features with GABAergic neurons and oligodendrocyte precursor cells, indicating a mix of tumoral and non-tumoral properties.
Auxiliary field Quantum Monte Carlo for dilute neutrons on the lattice.
Philos Trans A Math Phys Eng Sci
July 2024
We employ constrained path Auxiliary Field Quantum Monte Carlo (AFQMC) in the pursuit of studying physical nuclear systems using a lattice formalism. Since AFQMC has been widely used in the study of condensed-matter systems such as the Hubbard model, we benchmark our method against published results for both one- and two-dimensional Hubbard model calculations. We then turn our attention to cold atomic and nuclear systems.
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