Publications by authors named "R W Clough"
Currently for engineered nanomaterials (ENMs), there are no alternatives to bioaccumulation testing in fish as prescribed by OECD TG 305. New approaches are being sought, in order to reduce the numbers of animals used and address the ethical concerns associated with the use of vertebrates in such testing. This study aimed to demonstrate the value of an alternative method - the digestibility assay - as a tool to assess the bioaccumulation potential of ENMs.
View Article and Find Full Text PDFArterial carbon dioxide ([Formula: see text]) and posture influence the middle (MCAv) and posterior (PCAv) cerebral artery blood velocities, but there is paucity of data about their interaction and need for an integrated model of their effects, including dynamic cerebral autoregulation (dCA). In 22 participants (11 males, age 30.2 ± 14.
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- - During Hedgehog (Hh) signaling, the SMOOTHENED (SMO) receptor interacts with GLI transcription factors by blocking the activity of a key enzyme, protein kinase A (PKA-C).
- - The study reveals that GPCR kinase 2 (GRK2) moves to the primary cilium upon SMO activation, leading to SMO phosphorylation and facilitating its direct interaction with PKA-C.
- - This research highlights the essential role of GRK2 in Hh signaling, suggesting that GRKs may be important for direct interactions between GPCRs and other cellular proteins.
Article Synopsis
- Ambergris, a rare natural product found on beaches, was analyzed from a large piece of flotsam discovered in the Atlantic in 2019, highlighting its uncommon occurrence.
- Chemical tests showed that 95% of the outer subsamples dissolved in dichloromethane, revealing the presence of ambrein, a key compound in ambergris.
- The radiocarbon dating suggested the piece was from after the 1950s and contained a metal distribution dominated by copper and zinc, aligning with the diet of sperm whales that primarily consume squid.
Open surgical repair, often in the form of endarterectomy, is still the gold standard for steno-occlusive disease in the common femoral artery, despite the success of lower-risk endovascular alternatives in other peripheral arterial regions. Stenting in the common femoral artery is not widely adopted due to the proximity of the artery to the mobile hip joint, and the perceived risk this has on the stent structure due to kinking. The purpose of this review was to assess how hip movement contributes to the anatomical and biomechanical challenges proposed in the common femoral artery, and how these challenges impact the hemodynamics with both open surgical and endovascular stent treatments.
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