Publications by authors named "R W Cleary"
Incidence of surgical infection in cefazolin 3 g versus 2 g for colorectal surgery in obese patients.
Infect Control Hosp Epidemiol
January 2025
Objective: To compare the incidence of surgical site infection (SSI) between cefazolin 3 g and 2 g surgical prophylaxis in patients weighing ≥120 kg that undergo elective colorectal surgery.
Methods: A multicenter, retrospective cohort study was performed utilizing a validated database of elective colorectal surgeries in Michigan acute care hospitals. Adults weighing ≥120 kg who received cefazolin and metronidazole for surgical prophylaxis between 7/2012 and 6/2021 were included.
Article Synopsis
- The APDCRS has been running a standardized robotics course for colorectal fellows since 2011, aimed at improving surgical techniques in minimally invasive surgery.* -
- A survey of colorectal surgery graduates from 2014-2022 revealed that the majority had significant experience with laparoscopic and robotic surgeries, with an increasing trend in robotic case volumes over time.* -
- A large percentage of respondents (88.6%) felt that the course met their expectations and prepared them for using robotic techniques in their post-fellowship practices.*
Article Synopsis
- The study investigated how individuals with mild cognitive impairment (MCI) and dementia perform on social cognition tests, comparing these results to those without cognitive impairment.
- It involved a cross-sectional analysis of 321 older adults aged 80 and above, utilizing various social cognitive assessment tools and screening for levels of apathy and neurocognitive function.
- Findings indicated that participants with dementia showed notably worse social cognitive abilities compared to those with MCI and no cognitive impairment, particularly in emotional recognition and perspective-taking tasks.
Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study early tumor progression has hindered the development of effective therapies. Here, we develop engineered GBM organoids (eGBOs) harboring GBM subtype-specific oncogenic mutations to investigate the underlying transcriptional regulation of tumor progression.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) is a substantial cause of severe lower respiratory tract infections in infants, young children, older adults, and immunocompromised individuals. There is a vital need for effective therapeutics to prevent and/or treat severe RSV infection in these high-risk individuals. The development and pre-clinical testing of candidate RSV therapeutics could be accelerated by their evaluation in animals models that recapitulate bronchiolitis and bronchopneumonia; both hallmark features of severe RSV infection of humans.
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