Promotion of microfracture-mediated cartilage repair by the intra-articular injection of Mg2.

Aims: Magnesium ions (Mg) play an important role in promoting cartilage repair in cartilage lesions. However, no research has focused on the role of Mg combined with microfracture (MFX) in hyaline-like cartilage repair mediated by cartilage injury. This study aimed to investigate the beneficial effects of the combination of MFX and Mg in cartilage repair.

Study on metabolic disorders in rat liver induced by different times after scalds.

Previous studies have confirmed that burns and scalds can lead to metabolic disorders in the liver. However, the effects of severe burns at various time points on liver lipid metabolism disorders, as well as the relationship between these disorders and liver function, metabolism, and infection, have not yet been investigated.This study established a SD rat scald model, macroscopic observation of weight changes, histological staining, Western blot detection of fat browning and metabolic indicators, reverse transcription quantitative polymerase chain reaction analysis of the expression of liver new fat generation genes, determination of liver function and inflammatory indicators.

Insect Cytochrome P450 Database: An Integrated Resource of Genetic Diversity, Evolution and Function.

Insects, the most numerous and diverse group of animal species on Earth, have important interactions with humans through providing resources, transmitting diseases and damaging agricultural cultivars. Cytochrome P450 monooxygenases (P450s) are one of the most important protein families in insects implicated in the endogenous metabolism and detoxification of xenobiotics, including allelochemicals, insecticides and environmental pollutants. To better understand the evolution and function of insect P450s and support the development and application of insecticides for pest control, an integrated bioinformatics platform is highly desirable.

ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication.

Introduction: Viral infection usually stimulates a variety of host cell factors to modulate the life cycle of the virus. PIM1, a serine/threonine protein kinase widely involved in cell proliferation, survival, differentiation and apoptosis, was recently reported to be upregulated by Zika virus (ZIKV) infection. However, how ZIKV-PIM1 interactions affect the viral life cycle are not fully understood.

Spectroscopic characterization of buffer-gas-cooled lead monofluoride molecules in the BΣ(υ' = 0) ← XΠ(υ = 0) transition.

Establishing a nonzero measurement of the electron Electric Dipole Moment (eEDM) has long been a fundamental pursuit in atomic, molecular and optical physics, offering possible insights into new physics beyond the Standard Model. In this regard, lead monofluoride (PbF) has emerged as a potential candidate for measuring eEDM primarily due to its suitable properties such as the strong internal effective electric field, and eEDM-sensitive ground state with large Ω-doubling and small magnetic g factor. In the present work, we realized the production of a buffer-gas-cooled PbF molecular beam and characterized its high-resolution spectroscopy in the BΣ(υ'=0) ← XΠ(υ = 0) transition, including both direct absorption and laser-induced fluorescence spectroscopy.