Quantitative Whole Slide Assessment of Tumor-Infiltrating CD8-Positive Lymphocytes in ER-Positive Breast Cancer in Relation to Clinical Outcome.

There is a need for a reliable and reproducible quantification of the immune infiltrate within the heterogeneous microenvironment of tumors in order to support therapy selection in oncology. Here we present an automated, modular method for whole-slide image analysis of the spatial distribution of tumor-infiltrating CD8-positive lymphocytes. The method uses a deep learning tissue-type classification algorithm on the hematoxylin eosin (HE) stained tissue section to identify the central tumor (CT) and invasive margin (IM) of the tumor.

Deep learning assessment of breast terminal duct lobular unit involution: Towards automated prediction of breast cancer risk.

Terminal duct lobular unit (TDLU) involution is the regression of milk-producing structures in the breast. Women with less TDLU involution are more likely to develop breast cancer. A major bottleneck in studying TDLU involution in large cohort studies is the need for labor-intensive manual assessment of TDLUs.

An automatic vision-based malaria diagnosis system.

Malaria is a worldwide health problem with 225 million infections each year. A fast and easy-to-use method, with high performance is required to differentiate malaria from non-malarial fevers. Manual examination of blood smears is currently the gold standard, but it is time-consuming, labour-intensive, requires skilled microscopists and the sensitivity of the method depends heavily on the skills of the microscopist.

Interface, volume, and thermal attenuation of hot-electron spins in Ni80Fe20 and Co.

The relative importance of interface, volume, and thermal scattering in spin-dependent hot-electron transmission of magnetic trilayers is quantified. While interfaces produce significant attenuation (factor 2.2 per interface), the spin asymmetry is dominated by volume scattering.

Anisotropic spin-orbit scattering of hot-electron spins injected into ferromagnetic thin-films.

Anisotropic spin-orbit scattering of hot-electron spins in ferromagnets is examined by injecting a hot-electron current into the thin ferromagnetic base of a transistor and measuring the current attenuation as a function of the magnetization orientation. The transmission anisotropy is described by a simple model, from which we extract an effective spin-orbit scattering length of 420 nm for hot-electron spins in Ni(80)Fe(20), independent of temperature. The corresponding scattering time (<0.