Publications by authors named "R Vlok"
Objective: To describe the incidence of bleeding and thrombotic complications in VA-ECMO according to anticoagulation strategy.
Design: This systematic review and meta-analysis included randomised controlled trials (RCTs) and observational studies reporting bleeding and thrombotic complications in VA-ECMO. The incidence of primary outcomes according to anticoagulation drug and monitoring test was described.
Background: Acute brain injury due to conditions such as subarachnoid haemorrhage and traumatic brain injury are associated with physical, psychological, cognitive, emotional, and social deficits. Despite reductions in morbidity and mortality, there have been few significant changes in clinical practice. It has been suggested that heterogeneity in outcome assessment in studies has contributed to this limited progress.
View Article and Find Full Text PDFBackground: Whether intensive glucose control reduces mortality in critically ill patients remains uncertain. Patient-level meta-analyses can provide more precise estimates of treatment effects than are currently available.
Methods: We pooled individual patient data from randomized trials investigating intensive glucose control in critically ill adults.
Article Synopsis
- - The study aimed to estimate the incidence and outcomes of sepsis-associated acute kidney injury (SA-AKI) in ICU patients while examining how different definitions of SA-AKI affect these estimates.
- - Analyzing data from 189 studies, the research found that 40% of ICU patients with sepsis developed SA-AKI, with rates varying significantly based on the definition used, ranging from 26% to 57%.
- - Among participants with SA-AKI, about 48% had died by the study's end, while 10% of survivors remained dependent on dialysis, highlighting the serious complications associated with SA-AKI in ICU settings.
Background: Apnoeic oxygenation is the delivery of oxygen during the apnoeic phase preceding intubation. It is used to prevent respiratory complications of endotracheal intubation that have the potential to lead to significant adverse events including dysrhythmia, haemodynamic decompensation, hypoxic brain injury and death. Oxygen delivered by nasal cannulae during the apnoeic phase of intubation (apnoeic oxygenation) may serve as a non-invasive adjunct to endotracheal intubation to decrease the incidence of hypoxaemia, morbidity and mortality.
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