Pharmacogenetic guided drug therapy - how to deal with phenoconversion in polypharmacy?

Introduction: The prevalence of polypharmacy and the increasing availability of pharmacogenetic information in clinical practice have raised the prospect of data-driven clinical decision making when addressing the issues of drug-drug interactions and genetic polymorphisms in metabolizing enzymes. Inhibition of metabolizing enzymes in drug interactions can lead to genotype-phenotype discrepancies (phenoconversion) that reduce the relevance of individual pharmacogenetic information.

Areas Covered: The aim of this review is to provide an overview on existing models of phenoconversion and we discuss how phenoconversion models may be developed to estimate joint drug-interactions and genetic effects.

Dealing with adverse drug reactions in the context of polypharmacy using regression models.

Polypharmacy in older adults increases the risk of adverse drug reactions (ADRs), but studying this relationship is complex. In real-world data, the high number of medications, coupled with rare drug combinations, results in high-dimensional datasets that are difficult to analyze using conventional statistical methods. This study applies horseshoe and lasso regression for analyzing rare events in polypharmacy contexts, focusing on severe ADRs such as falls and bleedings.

Cognitions in antisocial personality and their association with "dark" traits.

Unlike the cognitions associated with depressive symptoms, little is known about those associated with antisocial personality and with its related traits ("dark traits"). Using the scrambled sentences task, an instrument from depression research, we investigated cognitions such as justifications (external blaming for one's behavior) and harm to others (based on the notion that some of these individuals enjoy harming or humiliating others) that we hypothesized may be prevalent in those high in antisocial personality traits. Confirming our hypothesis, these cognitions were associated with ratings on different antisocial personality scales and with antisocial and detachment scores in the alternative model of personality disorders of the DSM-5 (AMPD) in three non-clinical samples, but not with depressive symptoms or neuroticism.

When alienated from society, conspiracy theory belief gives meaning to life.

Background: Conspiracy theory belief - explaining the ultimate causes of social and political events with claims of secret conspiracies - is assumed to arise from a desire to make sense of uncertainty, especially in times of crisis. However, there is no compelling evidence that conspiracy theory belief actually fulfils this function, particularly in terms of evaluating one's life as meaningful. We posit that the adoption of conspiracy theory belief can be explained as a when a more proximal source of meaning, a sense of belonging to society, is threatened.