Publications by authors named "R Vitorino"
Minimally Invasive Versus Invasive Proteomics: Urine and Blood Biomarkers in Coronary Artery Disease.
Proteomics Clin Appl
January 2025
Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. This underlines the urgent need for effective biomarkers for early diagnosis, risk stratification, and therapeutic counseling. Proteomic signatures from plasma and urine have emerged as promising tools for these efforts, each offering unique advantages and challenges.
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- - The paper offers an in-depth analysis of biomarkers associated with head and neck cancer (HNC), discussing key proteins and genes that play significant roles in the disease's development and progression.
- - Important genes linked to HNC progression include AURKA, HMGA2, and others, while specific microRNAs (OncomiRs) are shown to promote tumor growth, with some, like hsa-miR-155-3p, indicating potential for prognosis.
- - Future research should focus on applying precision medicine and advanced therapies, including AI, to enhance personalized treatment approaches for better patient outcomes in HNC care.
Pitavastatin is commonly prescribed to treat hypercholesterolemia through the regulation of cholesterol biosynthesis. Interestingly, it has also demonstrated a great potential for treating brain tumors, although the detailed cytotoxic mechanism, particularly in glioblastoma, remains incompletely understood. This work explores the activity of pitavastatin in 2D and 3D glioblastoma models, in an attempt to provide a more representative and robust overview of its anticancer potential in glioblastoma.
View Article and Find Full Text PDFPlasma and breast milk adipokines in women across the first year postpartum and their association with maternal depressive symptoms and infant neurodevelopment: Protocol for the APPLE prospective cohort study.
PLoS One
October 2024
Article Synopsis
- Adiponectin and leptin are key hormones that impact the brain's function, particularly during the critical postpartum period for mothers and their infants, affecting maternal mood and infant development.
- * The study aims to investigate how levels of adiponectin and leptin in mothers’ blood and breast milk relate to infant neurodevelopment at 6 and 12 months old and maternal mental health during the first year postpartum.
- * A prospective cohort study is underway, having recruited 68 out of 95 mother-infant pairs as of September 2023, focusing on various factors like maternal depression, infant growth, and nutritional habits to improve healthcare strategies for mothers and infants.*
Snake venom composition varies at different levels. To date, comparative venom studies have seldom taken into account the role of habitat type in the occurrence of snake venom variation. Here we investigated the presence of venom variation across different populations of the Iberian asp viper (Vipera aspis zinnikeri) inhabiting two contrasting habitats: natural vs.
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