Design, Synthesis and Application of 1,4-disubstituted 1,2,3-triazole Based Chemosensors: A Promising Avenue.

The 1,2,3-triazole-based chemosensors, synthesized through Cu(I)-catalyzed azide-alkyne cycloaddition via 'click chemistry', offer a straightforward yet highly effective method for detecting metal cations and anions with remarkable accuracy, selectivity and sensitivity, making them invaluable across various fields such as chemistry, pharmacology, environmental science and biology. The selective recognition of these ions is crucial due to their significant roles in biological and physiological processes, where even slight concentration variations can have major consequences. The article reviews literature from 2017 to 2024, highlighting advancements in the synthesis of 1,2,3-triazole-based ligands and their application (along with sensing mechanism) for detection of various ions causing health and environmental hazards.

LC enantioseparation of active pharmaceutical ingredients using rationally synthesized CDRs and chiral molecules with high molar absorptivity.

The synthesis of optically active compounds requires determination of ee, er, and enantiomeric purity. The aim of the present paper is to review the synthesis of several chiral derivatizing reagents (CDRs) in a rational manner, which were successful for the separation and isolation of enantiomers of a variety of active pharmaceutical ingredients and other important and useful racemates. Besides, the application of (i) certain enantiomerically pure amines, either directly or by incorporating each of them as chiral auxiliary in difluorodinitrobenzene or cyanuric chloride moieties to construct the CDR, (ii) (S)-ketoprofen and (S)-levofloxacin as chiral platforms, and (iii) a few isothiocyanates, have been suitably included.