Publications by authors named "R Veeramanikandan"
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Although, many putative biomarkers are reported for AD, only a few have been validated in the clinical setting. Ubiquitin levels increase in cerebrospinal fluid (CSF) of patients with AD, but its diagnostic value is not clear.
View Article and Find Full Text PDFAssociation between apolipoprotein E genotype and cancer susceptibility: a meta-analysis.
J Cancer Res Clin Oncol
July 2014
Background: Apolipoprotein E (ApoE), a protein primarily involved in lipoprotein metabolism, occurs in three isoforms (E2, E3 and E4). Studies evaluating the association between APOE genotype and incidence of malignancies have given inconclusive results.
Objective: The objective of the present study was to analyze the association between APOE genotype and incidence of cancer by a meta-analysis.
Article Synopsis
- Scrub typhus, caused by Orientia tsutsugamushi, is a common bacterial infection in India and South Asia, and its immune response involves Toll-like receptors (TLRs) and heat shock proteins (HSPs).
- A study analyzed single-nucleotide polymorphisms (SNPs) in TLR4 and HSP70-2, focusing on their potential link to scrub typhus susceptibility in 137 patients and 134 controls.
- The results indicated higher prevalence of certain TLR4 mutations (D299G and T399I) in scrub typhus patients compared to controls, suggesting a significant association, while further research with larger samples could provide deeper insights into these genetic factors' impact on disease severity