Publications by authors named "R Varughese"
Background: Baseline lung allograft dysfunction (BLAD) after lung transplant is associated with an increased risk of dying, but the association with health-related quality of life (HRQL) and exercise capacity is not known. We hypothesized that BLAD would be associated with reduced HRQL and 6-min walk distance (6MWD) at 1 y post-lung transplant.
Methods: We analyzed patients who underwent lung transplants in our program from 2004 to 2018 who completed 1-y 36-item Short Form (SF-36) questionnaire and 6MWD testing.
GPR55, an orphan GPCR, holds significance in the context of neurological disorders and its activation is important for regulating neurological responses. This has led us to uncover and explore a set of ligands which may act as potential agonists. We have predicted the GPR55 structural model followed by molecular docking, dynamics simulation studies, free energy landscape and MMPBSA analyses to study the dynamic nature of GPR55 in the presence of different ligands.
View Article and Find Full Text PDFBackground: Conflicting guidance exists regarding the characterization of nebulization as an aerosol-generating procedure and subsequent risk of transmission of SARS-CoV-2 to healthcare workers.
Aim/objective: This study sought to address whether SARS-CoV-2 viral load distribution was impacted by bronchodilator delivery via nebulizer versus metered-dose inhaler (MDI).
Methods: Adults infected with COVID-19 were enrolled and received a single dose of albuterol sulfate nebulized solution (2.
Article Synopsis
- Individuals with opioid use disorder (OUD) need better access to treatment, and strategies like starting buprenorphine in emergency departments and using telemedicine can improve this access.
- A new referral process was tested that involved proactive outreach and telemedicine appointments to quickly connect patients with medications and ongoing care.
- The results showed high follow-through rates: 69.9% of participants completed all steps, leading to 126 new prescriptions for buprenorphine and 114 links to long-term treatment, indicating this method effectively prepares patients for receiving care.
Article Synopsis
- * The study involves predicting the 3D model of GPR78, conducting virtual screening for potential drug compounds, and simulating their interactions in a lipid environment to analyze binding energies and dynamics.
- * Findings reveal that lead compounds interact favorably with GPR78, indicating its dynamic nature and suggesting that targeting this orphan receptor could lead to new treatments for CNS-related disorders.