Determinants of sustainable work participation after spinal cord injury in The Netherlands.

Purpose: Work participation of persons with spinal cord injury (SCI) is lower compared to the overall Dutch population, with determinants largely unknown.

Aim: To identify the determinants of sustainable work participation for persons with SCI.

Methods: A cross-sectional multicenter study was conducted in eight Dutch rehabilitation centers.

Test-Retest Reliability and Agreement of the Work Ability Index-Single Item in Persons With Physical Disabilities.

Objective: To assess the test-retest reliability and agreement of the work ability index-single item (WAS) in persons with a physical disability.

Design: Test-retest study, with a 2-4 week interval. Test-retest reliability was computed using the intraclass correlation coefficient (ICC).

Relation between work hours, work control, work stress, and quality of life in persons with spinal cord injury.

Background: Work participation is related to a better quality of life (QoL) for people with spinal cord injury (SCI), however, the specific work characteristics that are related to QoL in people with SCI are largely unknown.

Objectives: To investigate which work characteristics are related to QoL in people with SCI.

Methods: Cross-sectional survey of people with SCI in the Netherlands.

Development of a microfluidic photochemical flow reactor concept by rapid prototyping.

The transfer from batch to flow chemistry is often based on commercial microfluidic equipment, such as costly complete reactor systems, which cannot be easily tailored to specific requirements of technologies such as DNA-encoded library technology (DELT), in particular for increasingly important photochemical reactions. Customized photoreactor concepts using rapid prototyping technology offer a modular, flexible, and affordable design that allows for adaptation to various applications. In order to validate the prototype reactors, a photochemical pinacol coupling reaction at 368 nm was conducted to demonstrate the transfer from batch to flow chemistry.

Development of an Automatable Affinity Purification Process for DNA-Encoded Chemistry.

DNA-encoded library technologies require high-throughput, compatible, and well automatable platforms for chemistry development, building block rehearsal, and library synthesis. An affinity-based process using Watson-Crick interactions was developed that enables purification of DNA-tagged compounds from complex reaction mixtures. The purification relies on a single-stranded DNA-oligonucleotide, called , which was covalently coupled to an agarose matrix and to which a DNA-compound conjugate from a DNA-encoded library (DEL) reaction can be reversibly annealed to.