Spiny mice (Acomys) have evolved cellular features to support regenerative healing.

Spiny mice (Acomys spp.) are warm-blooded (homeothermic) vertebrates whose ability to restore missing tissue through regenerative healing has coincided with the evolution of unique cellular and physiological adaptations across different tissue types. This review seeks to explore how these bizarre rodents deploy unique or altered injury response mechanisms to either enhance tissue repair or fully regenerate excised tissue compared to closely related, scar-forming mammals.

Running after two hares in visual working memory: Exploring retrospective attention to multiple items using simulation, behavioral outcomes, and eye tracking.

Multi-item retro-cueing effects refer to better working memory performance for multiple items when they are cued after their offset compared to a neutral condition in which all items are cued. However, several studies have reported boundary conditions, and findings have also sometimes failed to replicate. We hypothesized that a strategy to focus on only one of the cued items could possibly yield these inconsistent patterns.

Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids.

Therapeutic nucleic acids (TNAs) including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) have emerged as promising treatment strategies for a wide variety of diseases, offering the potential to modulate gene expression with a high degree of specificity. These small, synthetic nucleic acid-like molecules provide unique advantages over traditional pharmacological agents, including the ability to target previously "undruggable" genes. Despite this promise, several biological barriers severely limit their clinical efficacy.

The Road to Recovery: A Two-Year Longitudinal Analysis of Mental Health Among University Students During and After the COVID-19 Pandemic.

Longitudinal research into the impact of COVID-19 on university students' mental health beyond the pandemic is lacking. This study aims to address the gap in the literature by tracking the mental health of university students over a two-year period, spanning the COVID-19 pandemic and its aftermath. A two-year longitudinal study surveyed a sample of university students ( = 302) three times between May 2020 and May 2022.

Correction of Lower Lip Malposition With Fascia Lata Slings Following Anterior Mandibular Resection.

Lower lip malposition can occur after anterior mandibular resection as a result of the loss of soft tissue lip attachments. We report our technique of cranial suspension of the lower lip with fascia lata slings to improve lip position. Correction of lip ptosis results in cessation of drooling, improved oral intake, and restoration of facial aesthetics.