Publications by authors named "R V Thakker"
Current models for the study of neuroendocrine tumours (NETs) are severely limited. While (e.g.
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- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can be either hormone-secreting or non-secreting, have serious health implications, and an average survival of 75-124 months.
- Research shows that key genes involved in the tumor's development, especially epigenetic regulators like MEN1, DAXX, and ATRX, are often mutated, but their effects are not well understood.
- The calcium sensing receptor (CaSR) is significantly reduced in GEP-NETs, potentially due to DNA methylation and chromatin modifications, suggesting it functions as a tumor suppressor by inhibiting cell growth in pancreatic NETs.
The treatment of cardiac thrombus after ST-segment elevation myocardial infarction (STEMI) is anticoagulation. There are conflicting data on the effectiveness and safety of novel oral anticoagulants (NOACs) versus warfarin. Using the national Medicare data, we identified patients with an admission diagnosis of STEMI and cardiac thrombus within 6 months after STEMI.
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- * Researchers studied a Caucasian family with a history of AFFs and identified a rare genetic variant in the LOXL4 gene that may be associated with increased susceptibility to these fractures.
- * The LOXL4 gene is involved in collagen production, and the variant may disrupt collagen metabolism, leading to microdamage in bones and poor healing, as indicated by tests on cells from affected individuals.
Article Synopsis
- A systematic review of five clinical trials involving over 21,000 patients analyzed the effectiveness of abbreviated ticagrelor-based dual antiplatelet therapy (DAPT) compared to the standard 12-month therapy in patients with acute coronary syndrome (ACS).
- Results indicated that abbreviated DAPT (≤3 months) significantly reduced all-cause mortality risk (risk ratio 0.78) without differences in major cardiac events like myocardial infarction or stent thrombosis.
- Additionally, the abbreviated DAPT was linked to a lower risk of major bleeding complications, suggesting potential benefits in reducing adverse outcomes while maintaining similar effectiveness for key cardiac events.