Structural Insights and Potential Inhibitor Identification Based on the Benzothiazole Core for Targeting Pteridine Reductase 1.

Leishmaniasis is reported as the second most common protozoonosis, with the highest prevalence and mortality rate. Among the Leishmania drug targets, Pteridine Reductase 1 of (PTR1) proved to be promising because Leishmania is auxotrophic for folates. Thus, this study employed a combination of ligand- and structure-based approaches to screen new benzothiazole compounds as PTR1 inhibitor candidates.

Safety and immunogenicity of different 17DD yellow fever vaccines in golden-headed tamarins (Leontopithecus chrysomelas): Inhibition of viremia and RNAemia after homologous live-attenuated vaccination.

Yellow fever (YF) is a viral disease that affects both humans and non-human primates (NHPs). Neotropical monkeys are more severely stricken by YF and the impact of the disease can be devastating to the endangered golden-headed lion tamarins (GHLTs, Leontopithecus chrysomelas). Susceptible GHLTs were immunized with the commercial Brazilian YF 17DD live attenuated vaccine or two other experimental non-replicating YF vaccines: a purified whole-virus, b-propiolactone-inactivated vaccine and a plant-derived recombinant subunit vaccine.

Association of LDL-cholesterol with prognosis in patients admitted for acutely decompensated heart failure.

Introduction And Objectives: The association of low-density lipoprotein cholesterol (LDL-C) levels and prognosis in patients with heart failure (HF) remains uncertain. This study aimed to evaluate the prognostic significance of LDL-C in patients admitted for acutely decompensated HF and establish a safety cut-off value in this population.

Methods: This retrospective, observational study included 167 consecutive patients admitted for acute HF.

Survival of teeth with external cervical resorption after Internal and External Repair: A Systematic Review.

Background: To analyze the survival rate of teeth affected by invasive cervical resorption after internal and external repair.

Material And Methods: A search was conducted in PubMed/Medline, Web of Science, Embase, Scopus, the Cochrane Library, and gray literature at the DANS Easy Archive until September 2023. The selected studies were subjected to risk assessment of bias, and the quality of evidence was assessed using the Newcastle Ottawa Scale.

THE RELATIONSHIP BETWEEN CHOLESTEROL LEVELS AND THYROID EYE DISEASE.

Background: Thyroid eye disease (TED) is the most prevalent extrathyroidal manifestation of Graves' disease (GD). Emerging evidence suggests a relationship between elevated total and LDL cholesterol levels and TED. This study aimed to investigate this correlation in the Brazilian population by analyzing data from two tertiary care centers.